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- and 
-Tocotrienol Concentrations in Skin and Adipose Tissue of Rats Fed the Tocotrienol-Rich Fraction Extracted from Palm Oil1
Department of Food and Nutrition, School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan
2To whom correspondence should be addressed. E-mail: kanaey{at}food.sugiyama-u.ac.jp
ABSTRACT
The metabolism of tocotrienol remains unclear. We studied the
distribution of tocotrienol in rats fed the tocotrienol-rich
fraction extracted from palm oil. We have previously shown that dietary
sesame seeds markedly elevate the tocopherol concentration in rats. In
this study, we also examined the effect of dietary sesame seeds on the
tocotrienol concentration. In experiment 1, rats (4-wk-old) were fed
the diet with 
-tocopherol alone or with - and 
-tocotrienols.
In experiment 2, the effect of dietary sesame seeds on tocopherol and
tocotrienol concentrations in rats fed the diet with tocopherol and
tocotrienol was studied. The rats were fed the experimental diet for 8
wk in both experiments. - and -Tocotrienols accumulated in the
adipose tissue and skin, but not in plasma or other tissues, of the
rats fed tocotrienols. Dietary sesame seeds elevated (P
< 0.05) tocotrienol concentrations in the adipose tissue and
skin, but did not affect their concentrations in other tissues or in
plasma. The -tocopherol concentration in all tissues and plasma of
rats fed -tocopherol was extremely low but was elevated
(P < 0.05) in many tissues by feeding sesame
seeds. These data suggest that the transport and tissue uptake of
vitamin E isoforms are different. Dietary sesame seeds elevate the
concentrations of both tocopherols and tocotrienols.
KEY WORDS: • adipose tissue • sesame seeds • skin • tocotrienol • vitamin E • rats
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