QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Shah, S. Articles by Semba, R. D. Search for Related Content PubMed PubMed Citation Articles by Shah, S. Articles by Semba, R. D.

---

Human Nutrition and Metabolism

Severity of Human Immunodeficiency Virus Infection Is Associated with Decreased Phase Angle, Fat Mass and Body Cell Mass in Adults with Pulmonary Tuberculosis Infection in Uganda¹

Snehal Shah^*, Christopher Whalen, Donald P. Kotler^**, Harriet Mayanja, Alice Namale, George Melikian, Roy Mugerwa and Richard D. Semba

The Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA; Tuberculosis Research Unit, Department of Epidemiology, Case Western Reserve University, Cleveland, OH; Division of Gastroenterology, Department of Medicine, St. Luke’s-Roosevelt Hospital Center, New York, NY; Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD; and Department of Medicine, Makerere University, Kampala, Uganda ^{** *}

²To whom correspondence should be addressed. E-mail: rdsemba{at}jhmi.edu

ABSTRACT

Although coinfection with tuberculosis and human immunodeficiency virus (HIV) is emerging as a major problem in many developing countries, nutritional status has not been well characterized in adults with tuberculosis and HIV infection. We compared nutritional status between 261 HIV-positive and 278 HIV-negative adults with pulmonary tuberculosis in Kampala, Uganda, using anthropometry and bioelectrical impedance analysis. Among 163 HIV-positive and 199 HIV-negative men, intracellular water–to–extracellular water (ICW:ECW) ratio was 1.48 ± 0.26 and 1.59 ± 0.48 (P = 0.006) and phase angle was 5.42 ± 1.05 and 5.76 ± 1.30 (P = 0.009), respectively. Among 98 HIV-positive and 79 HIV-negative women, ICW:ECW was 1.19 ± 0.16 and 1.23 ± 0.15 (P = 0.11) and phase angle was 5.35 ± 1.27 and 5.43 ± 0.93 (P = 0.61), respectively. There were no significant differences in BMI, body cell mass, fat mass or fat-free mass between HIV-positive and HIV-negative adults. Among HIV-positive subjects, BMI, ICW:ECW, body cell mass, fat mass and phase angle were significantly lower among those with CD4⁺ lymphocytes 200 cells/µL compared with those who had >200 cells/µL. In sub-Saharan Africa, coinfection with pulmonary tuberculosis and HIV is associated with smaller body cell mass and intracellular water, but not fat-free mass, and by large differences in ICW:ECW and phase angle .

KEY WORDS: • acquired immune deficiency syndrome • AIDS • human immunodeficiency virus infection • HIV • malnutrition • body composition • bioelectrical impedance • tuberculosis