![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
,2
*
Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, The Netherlands;
Department of Gastroenterology, University Medical Center Nijmegen, The Netherlands;
**
Emma Children’s Hospital, Academic Medical Center, University of Amsterdam, The Netherlands; and
Department of Food and Nutrition, Faculty of Agriculture, National University of Benin, Cotonou, Benin, West Africa
2To whom correspondence should be addressed. E-mail: clive.west{at}staff.nutepi.wau.nl.
Iodine deficiency control programs have greatly reduced iodine deficiency disorders worldwide. For monitoring changes in iodine status, different indicators may be used. The aim of this study was to evaluate the suitability of indicators of iodine status and thyroid function, thyroglobulin (Tg), thyroid-stimulating hormone (TSH) and free thyroxine (FT4) in serum, thyroid volume and urinary iodine concentration, in iodine-deficient schoolchildren under conditions of increasing iodine supply. The study was established as a double-blind, placebo-controlled oral administration of a single dose of iodized oil to schoolchildren (7–10 y old), living in an iodine-deficient area of Benin, with an observation period of 10 mo. However, 3–4 mo after supplementation, iodized salt became available in the area. The study population therefore comprised an iodized oil–supplemented group and a nonsupplemented group, both of which had variable, uncontrolled intakes of iodized salt during the last 6 mo of the study. Initial mean serum concentrations of TSH and FT4 were within the normal range, whereas serum Tg concentration, urinary iodine concentration and thyroid volume were indicative of moderate-to-severe iodine deficiency. At the end of the study, all indicators had improved significantly, except thyroid volume, which had decreased only in the supplemented group. The supplemented group also still had significantly lower serum Tg and higher urinary iodine concentrations than the nonsupplemented group. Serum Tg and urinary iodine concentrations are the indicators most influenced by a changing iodine supply. Current normal reference ranges of serum concentrations of TSH and FT4 are too wide for detecting iodine deficiency in this age group.
KEY WORDS: • iodine deficiency • indicators • schoolchildren • Benin
This article has been cited by other articles:
|
|
 |
|
  D. Ristic-Medic, Z. Piskackova, L. Hooper, J. Ruprich, A. Casgrain, K. Ashton, M. Pavlovic, and M. Glibetic Methods of assessment of iodine status in humans: a systematic review Am. J. Clinical Nutrition, June 1, 2009; 89(6): 2052S - 2069S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Zimmermann, B. de Benoist, S. Corigliano, P. L. Jooste, L. Molinari, K. Moosa, E. A. Pretell, Z. S. Al-Dallal, Y. Wei, C. Zu-Pei, et al. Assessment of Iodine Status Using Dried Blood Spot Thyroglobulin: Development of Reference Material and Establishment of an International Reference Range in Iodine-Sufficient Children J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 4881 - 4887. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Zimmermann Assessing Iodine Status and Monitoring Progress of Iodized Salt Programs J. Nutr., July 1, 2004; 134(7): 1673 - 1677. [Abstract] [Full Text]
|
|
|
|
|
|
M. B Zimmermann, D. Moretti, N. Chaouki, and T. Torresani Development of a dried whole-blood spot thyroglobulin assay and its evaluation as an indicator of thyroid status in goitrous children receiving iodized salt Am. J. Clinical Nutrition, June 1, 2003; 77(6): 1453 - 1458. [Abstract] [Full Text] [PDF]
|
|
