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Articles

Dietary Methionine Is Involved in the Etiology of Neural Tube Defect–Affected Pregnancies in Humans^{1 ,2}

Hylan D. Shoob³, Roger G. Sargent^*, Shirley J. Thompson, Robert G. Best, J. Wanzer Drane and Aunyika Tocharoen

Departments of Epidemiology and Biostatistics and ^* Health Promotion and Education, School of Public Health, University of South Carolina, Columbia, SC 29208 and Department of Obstetrics and Gynecology, School of Medicine, University of South Carolina, Columbia, SC 29203

³To whom correspondence should be addressed. E-mail: arad1{at}aol.com.

Research has provided evidence of the role of multivitamin supplementation in the prevention of neural tube defects (NTD). Failure of the neural tube to close is one of the most frequent and severe human developmental defects. The etiology of NTD is complex, encompassing genetic, dietary and environmental factors. The purpose of this study was to explore the relationship between maternal dietary intake of methionine and the risk of having a NTD-affected pregnancy. We hypothesized that women with high maternal dietary methionine intake were at a decreased risk for a NTD. Combinations of methionine, folate and vitamin B-12 intakes and NTD risk were also examined. Data from a 5-y, population-based, case-control study of 170 NTD-affected pregnancies and 269 controls were provided by the South Carolina NTD Surveillance, Prevention, and Research Project. There was a 30–55% lower NTD risk among women whose average daily dietary intake of methionine was greater than the lowest quartile of intake (>1580 mg/d). The odds ratios associated with the three quartiles of methionine intake > 1580 mg/d after adjusting for energy, race and body mass index were 0.72 (P < 0.07), 0.68 (P < 0.07) and 0.45 (P < 0.06), respectively. These findings indicate that a reduction in the risk of having a NTD-affected pregnancy is associated with maternal dietary intake of methionine (3 mo pre- to 3 mo postconception). This finding is consistent with the hypothesis that methionine plays a role in the etiology of NTD and suggests the need for further research in the area of maternal diet and pregnancy.

KEY WORDS: • methionine • neural tube defects • pregnancy • maternal diet • humans

This article has been cited by other articles:

				W. D. Rees, F. A. Wilson, and C. A. Maloney Sulfur Amino Acid Metabolism in Pregnancy: The Impact of Methionine in the Maternal Diet J. Nutr., June 1, 2006; 136(6): 1701S - 1705S. [Abstract] [Full Text] [PDF]