QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Huda, S. N. Articles by Tomkins, A. Search for Related Content PubMed PubMed Citation Articles by Huda, S. N. Articles by Tomkins, A.

---

Article

Cognitive and Motor Functions of Iodine-Deficient but Euthyroid Children In Bangladesh Do not Benefit from Iodized Poppy Seed Oil (Lipiodol)¹

Institute of Nutrition and Food Science, University of Dhaka, Dhaka 1000, Bangladesh and ^* Centre for International Child Health, Institute of Child Health, London WC1N 1EH, UK

²To whom correspondence should be addressed. E-mail: SMcgregor{at}ich ucl.ac.uk.

Iodine supplementation before pregnancy in iodine-deficient women prevents cretinism and neuromotor deficits in their offspring. It is unclear whether iodine supplementation benefits cognitive function in iodine-deficient school-aged children. We therefore conducted a double-blind, randomized, controlled trial of the effects of iodized poppy seed oil (Lipiodol) on cognitive and motor function and weight gain of iodine-deficient school children. The study was conducted with 305 children in grades 1 and 2 from 10 primary schools in two iodine-deficient areas in Bangladesh. The children were stratified by school and grade and randomly assigned to receive 400 mg of oral Lipiodol or a placebo. All children were given a battery of cognitive and motor function tests and had their weights, serum thyroxine (T₄) and thyroid-stimulating hormone (TSH) and urinary iodine levels measured before and 4 mo after the intervention. On enrollment, both groups were moderately iodine deficient (median urinary iodine values: placebo group = 3.3 µmol/L, n = 148; iodine group = 3.1 µmol/L, n = 152; goiter prevalence in both groups >95%). However, their T₄ and TSH levels were within the normal range. After 4 mo, there was a significant treatment effect on urinary iodine levels (P < 0.0001), but the levels of the treated group were still below normal (median = 7.9 µmol/L). No significant differences were found in T₄ and TSH levels, weight gain, cognitive or motor function. The findings suggest that Lipiodol supplementation in moderately iodine-deficient children with normal T₄ levels is unlikely to benefit their cognitive function. However, it remains possible that other iodine preparations may have benefits.

KEY WORDS: • iodine deficiency disorders • iodized poppy seed oil • cognitive functions • school children • urinary iodine excretion

This article has been cited by other articles:

				R. C Gordon, M. C Rose, S. A Skeaff, A. R Gray, K. M. Morgan, and T. Ruffman Iodine supplementation improves cognition in mildly iodine-deficient children Am. J. Clinical Nutrition, November 1, 2009; 90(5): 1264 - 1271. [Abstract] [Full Text] [PDF]

				M. B. Zimmermann Iodine Deficiency Endocr. Rev., June 1, 2009; 30(4): 376 - 408. [Abstract] [Full Text] [PDF]

				D. Ristic-Medic, Z. Piskackova, L. Hooper, J. Ruprich, A. Casgrain, K. Ashton, M. Pavlovic, and M. Glibetic Methods of assessment of iodine status in humans: a systematic review Am. J. Clinical Nutrition, June 1, 2009; 89(6): 2052S - 2069S. [Abstract] [Full Text] [PDF]

				M. B. Zimmermann, P. L. Jooste, N. S. Mabapa, X. Mbhenyane, S. Schoeman, R. Biebinger, N. Chaouki, M. Bozo, L. Grimci, and J. Bridson Treatment of Iodine Deficiency in School-Age Children Increases Insulin-Like Growth Factor (IGF)-I and IGF Binding Protein-3 Concentrations and Improves Somatic Growth J. Clin. Endocrinol. Metab., February 1, 2007; 92(2): 437 - 442. [Abstract] [Full Text] [PDF]