QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hayase, K. Articles by Yokogoshi, H. Search for Related Content PubMed PubMed Citation Articles by Hayase, K. Articles by Yokogoshi, H.

---

Article

17-ß-Estradiol Affects Brain Protein Synthesis Rate in Ovariectomized Female Rats¹

Kazutoshi Hayase², Miyuki Tanaka, Kazuyo Tujioka, Emi Hirano, Osami Habuchi^* and Hidehiko Yokogoshi

Departments of Home Economics and ^* Life Science, Aichi University of Education, Kariya, Aichi 448-8542, Japan and Laboratory of Nutritional Biochemistry, School of Food and Nutritional Sciences, The University of Shizuoka, Yada, Shizuoka 422-8526, Japan

²To whom correspondence should be addressed. E-mail: khayase{at}auecc.aichi-edu.ac.jp

The purpose of this study was to determine whether 17-ß-estradiol affects the rate of brain protein synthesis in ovariectomized female rats. Experiments were conducted on three groups of 12-wk-old female rats: group 1 were ovariectomized to reduce the level of plasma estradiol, group 2 were ovariectomized and treated with estradiol and group 3 were sham-operated controls. The fractional rates of protein synthesis in brain of ovariectomized rats treated with estradiol were significantly greater than that in ovariectomized rats without estradiol treatment. In the cerebral cortex and cerebellum, the RNA activity [g protein synthesized/(g RNA · d)] significantly correlated (r > 0.87, P < 0.001) with the fractional rate of protein synthesis. The RNA concentration (mg RNA/g protein) was not related to the fractional rate of protein synthesis in any organ. The results suggest that estrogen treatment of ovariectomized female rats is likely to increase the rate of protein synthesis in the brain and that RNA activity is at least in part related to the fractional rate of brain protein synthesis.

KEY WORDS: • 17-ß-estradiol • ovariectomy • protein synthesis • brain • rats

This article has been cited by other articles:

				Y. Kimura, K. K. Buddington, and R. K. Buddington The Influence of Estradiol and Diet on Small Intestinal Glucose Transport in Ovariectomized Rats Experimental Biology and Medicine, March 1, 2004; 229(3): 227 - 234. [Abstract] [Full Text] [PDF]

				S. Lyou, E. Hirano, K. Tujioka, Y. Mawatari, K. Hayase, S. Okuyama, and H. Yokogoshi Dietary Genistein Affects Brain Protein Synthesis Rates in Ovariectomized Female Rats J. Nutr., July 1, 2002; 132(7): 2055 - 2058. [Abstract] [Full Text] [PDF]