![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut 06269-4017
1To whom correspondence should be addressed. E-mail: maria-luz.fernandez{at}uconn.edu
Guinea pigs carry the majority of their plasma cholesterol in LDL, making them a unique animal model with which to study hepatic cholesterol and lipoprotein metabolism. In this review, the benefits and advantages of using this particular model are discussed. How dietary factors such as soluble fiber, cholesterol and fatty acids that vary in saturation and chain length affect hepatic cholesterol homeostasis and influence the synthesis, intravascular processing and catabolism of lipoproteins is reviewed. In addition, alterations in hepatic cholesterol metabolism and plasma lipoproteins as affected by treatment with cholestyramine or 3-hydroxyl-3-methylglutaryl coenzyme A reductase inhibitors, exercise, marginal intake of vitamin C, ovariectomy (a model for menopause) and similarities to the human situation are addressed. A review of guinea pigs as models for early atherosclerosis development is also presented.
KEY WORDS: • Guinea pigs • lipoprotein metabolism • hepatic cholesterol metabolism • soluble fiber • atherosclerosis.
This article has been cited by other articles:
|
|
 |
|
  M. Torres-Gonzalez, S. Shrestha, M. Sharman, H. C. Freake, J. S. Volek, and M. L. Fernandez Carbohydrate Restriction Alters Hepatic Cholesterol Metabolism in Guinea Pigs Fed a Hypercholesterolemic Diet J. Nutr., October 1, 2007; 137(10): 2219 - 2223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Zern, K. L. West, and M. L. Fernandez Grape Polyphenols Decrease Plasma Triglycerides and Cholesterol Accumulation in the Aorta of Ovariectomized Guinea Pigs J. Nutr., July 1, 2003; 133(7): 2268 - 2272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. West, T. Ramjiganesh, S. Roy, B. T. Keller, and M. L. Fernandez 1-[4-[4[(4R,5R)-3,3-Dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl]phenoxy]butyl]-4-aza-1-azoniabicyclo[2.2.2]octane Methanesulfonate (SC-435), an Ileal Apical Sodium-Codependent Bile Acid Transporter Inhibitor Alters Hepatic Cholesterol Metabolism and Lowers Plasma Low-Density Lipoprotein-Cholesterol Concentrations in Guinea Pigs J. Pharmacol. Exp. Ther., October 1, 2002; 303(1): 293 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Ewart, L. K. Cole, J. Kralovec, H. Layton, J. M. Curtis, J. L. C. Wright, and M. G. Murphy Fish Oil Containing Phytosterol Esters Alters Blood Lipid Profiles and Left Ventricle Generation of Thromboxane A2 in Adult Guinea Pigs J. Nutr., June 1, 2002; 132(6): 1149 - 1152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Romero, K. L. West, T. Zern, and M. L. Fernandez The Seeds from Plantago ovata Lower Plasma Lipids by Altering Hepatic and Bile Acid Metabolism in Guinea Pigs J. Nutr., June 1, 2002; 132(6): 1194 - 1198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ramjiganesh, S. Roy, H. C. Freake, J. C. McIntyre, and M. L. Fernandez Corn Fiber Oil Lowers Plasma Cholesterol by Altering Hepatic Cholesterol Metabolism and Up-Regulating LDL Receptors in Guinea Pigs J. Nutr., March 1, 2002; 132(3): 335 - 340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. V. Gupta and P. Khosla Palmitic and Stearic Acids Similarly Affect Plasma Lipoprotein Metabolism in Cynomolgus Monkeys Fed Diets with Adequate Levels of Linoleic Acid J. Nutr., August 1, 2001; 131(8): 2115 - 2120. [Abstract] [Full Text] [PDF]
|
|
