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Research Communication

Blood Glucose and Insulin Concentrations Are Reduced in Humans Administered Sucrose with Inosine or Adenosine¹

Yasunori Fukumori^*, Hiroyuki Takeda, Takuji Fujisawa^**, Kosuke Ushijima^**, Shuichi Onodera^* and Norio Shiomi^*2

^* Department of Food Science, Graduate School of Dairy Science Research, Rakuno Gakuen University, Ebetsu 069-8501, Japan, Department of General Foods, The Hokuren Federation of Agriculture Corporation, Sapporo 060-8651, Japan, and ^** Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume 830, Japan

²To whom correspondence should be addressed.

Recently we found that some nucleosides such as inosine or adenosine inhibited -glucosidase from rat intestine. The aim of this study was to determine whether these nucleosides are sucrase inhibitors in humans as well as rats. Blood glucose and insulin responses were examined in 23 healthy volunteers (18 males and 5 females) administered sucrose with inosine and 8 (males) administered sucrose with adenosine. The initial increase in plasma glucose and serum insulin concentrations at 30 min after loading sucrose (50 g) alone were significantly reduced by co-administration of inosine (2.5 and 1.0 g) or adenosine (2.5 g). The total increases in the areas under the plasma glucose and serum insulin concentration curves for 3 h after administration of the same amount of sucrose with inosine were also significantly less than those when the volunteers were administered sucrose alone. These results in humans agree with the findings obtained in our previous studies in rats. These nucleosides may be used as one of the components of artificial sweeteners when mixed with sucrose and may be useful as food additives to suppress increases in blood glucose and insulin.

KEY WORDS: • human volunteers • inosine, adenosine • blood glucose, insulin • -glucosidase inhibitor • diabetes