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Article

Protein Feeding Pattern Does Not Affect Protein Retention in Young Women¹

Marie-Agnès Arnal², Laurent Mosoni, Yves Boirie^*, Marie-Louise Houlier, Liliane Morin^*, Elisabeth Verdier^*, Patrick Ritz^*, Jean-Michel Antoine, Jacques Prugnaud, Bernard Beaufrère^* and Philippe Patureau Mirand³

Unité d’Etude du Métabolisme Azoté, Institut National de la Recherche Agronomique et Centre de Recherche en Nutrition Humaine, Clermont-Ferrand-Theix, France; ^* Laboratoire de Nutrition Humaine, Université d’Auvergne et Centre de Recherche en Nutrition Humaine, Clermont-Ferrand, France; and Société Danone, 92350 Le Plessis-Robinson, France

²To whom correspondence should be addressed.

This study was undertaken to determine whether a pulse protein feeding pattern was more efficient than a spread pattern to improve protein anabolism in young women as was already shown in elderly women. After a 15-d adaptive period [1.2 g protein/(kg fat-free mass · d)], 16 young women (age 26 ± 1 y) were given a 14-d diet providing 1.7 g protein/(kg fat-free mass · d), using either a pulse pattern (protein consumed mainly in one meal, n = 8), or a spread pattern (spreading daily protein intake over four meals, n = 8). Nitrogen balance was determined at the end of both the 15-d adaptive and the 14-d experimental periods. Whole-body protein turnover was determined at the end of the 14-d experimental period using [¹⁵N]glycine as an oral tracer. Nitrogen balance was 17 ± 5 mg N/(kg fat-free mass · d) during the adaptive period. It was higher during the experimental period, but not significantly different in the women fed the spread or the pulse patterns [59 ± 12 and 36 ± 8 mg N/(kg fat-free mass · d) respectively]. No significant effects of the protein feeding pattern were detected on either whole-body protein turnover [5.5 ± 0.2 vs. 6.1 ± 0.3 g protein/(kg fat-free mass · d) for spread and pulse pattern, respectively] or whole-body protein synthesis and protein breakdown. Thus, in young women, these protein feeding patterns did not have significantly different effects on protein retention.

KEY WORDS: • aging • protein feeding pattern • nitrogen balance • protein turnover • women

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