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Métabolisme Minéral, Laboratoire des Maladies Métaboliques et Micronutriments (U3M), I.N.R.A. Clermont-Ferrand/Theix, 63122 Saint Genès Champanelle, France;
*
ENITA de Bordeaux, 33175 Gradignan cedex, France, LBRP, Université Bordeaux I, 33405 Talence cedex, France; and
LPA, UFR Biosciences, Université de Cocody, Abidjan 22, Côte d’Ivoire
1To whom correspondence should be addressed.
We investigated the ability of genistein and daidzein, two soybean
isoflavones, compared with that of 17
-ethinylestradiol, to prevent
bone loss in ovariectomized rats, a model for postmenopausal
osteoporosis. Female Wistar rats (n = 65; 12 mo
old) were either sham-operated (SH; n = 13) or
ovariectomized (OVX; n = 52). On d 0, OVX rats were
randomly assigned to groups as follows: 13 received genistein [G; 10
µg/(g body weight · d)], 13 were treated with
daidzein [D; 10 µg/(g body weight · d)], 13
received 17-ethinylestradiol [E2; 30
µg/kg body weight · d)] and 13 were untreated
(OVX). Compounds were mixed with a soy protein–free powdered
semipurified diet and given orally for 3 mo. On d 90, the bone mineral
density (BMD) in lumbar vertebrae, femur and its metaphyseal and
diaphyseal zones (rich in cancellous and cortical bone, respectively)
was lower in OVX than in SH (P < 0.01). In D or
E2, the four BMD were not different from SH, whereas in G,
only the diaphyseal BMD was not different from SH. Image analysis
performed in the distal femur metaphysis revealed that the cancellous
bone area was lower in OVX than in SH (P < 0.01).
Only the area in D was not different from that in SH. Finally, the bone
turnover, which was higher in OVX than in SH (P < 0.005 and P < 0.05 for plasma osteocalcin
concentration and urinary deoxypyridinoline excretion, respectively),
was not different in G, D or E2 compared with SH.
Therefore, consumption of 17-ethinylestradiol or daidzein was more
efficient than genistein in preventing ovariectomy-induced bone
loss in rats.
KEY WORDS: • genistein • daidzein • prevention • bone • rats
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