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1;
*
Institut Paul Lambin and
Université Catholique de Louvain, B1200 Brussels, Belgium
1To whom correspondence should be addressed.
The partial enzymatic hydrolysis of chicory inulin (GFn; 2 
n 60) yields an oligofructose preparation that
is composed of both GFn-type and Fn-type oligosaccharides (2
n 7; 2 m 7), where G is
glucose, F is fructose, and n is the number of ß(2
1) bound
fructose moieties. Human studies have shown that feeding GFn-type
oligomers significantly modifies the composition of the fecal
microflora especially by increasing the number of bifidobacteria. The
experiments reported here were used to test the hypothesis that the
Fn-type molecules have the same property. During a controlled
feeding study, 8 volunteers (5 females and 3 males) consumed 8 g/d of
an Fn-rich product for up to 5 wk. Fecal samples were collected and
analyzed for total anaerobes, bifidobacteria, lactobacilli,
bacteroides, coliforms and Clostridium perfringens. Both
2 and 5 wk of oligofructose feeding resulted in a selective increase in
bifidobacteria (P < 0.01). In addition, a daily
intake of 8 g of the Fn-type oligofructose preparation reduced
fecal pH and caused little intestinal discomfort.
KEY WORDS: • prebiotics • inulin • oligofructose • humans
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