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Article

Carotenoid Bioavailability in Humans from Tomatoes Processed in Different Ways Determined from the Carotenoid Response in the Triglyceride-Rich Lipoprotein Fraction of Plasma after a Single Consumption and in Plasma after Four Days of Consumption

Karin H. van het Hof^*1, Ben C. J. de Boer^*, Lilian B. M. Tijburg^*, Bianca R. H. M. Lucius^*, Itske Zijp^*, Clive E. West, Joseph G. A. J. Hautvast and Jan A. Weststrate^*

^* Unilever Research Vlaardingen, Vlaardingen, The Netherlands; and Division of Human Nutrition and Epidemiology, Wageningen Agricultural University, Wageningen, The Netherlands

¹To whom correspondence should be addressed.

Tomatoes are the main dietary source of lycopene, and the bioavailability of lycopene from tomato paste is higher than that from fresh tomatoes. We investigated systematically the effect of mechanical homogenization and heating on the bioavailability of carotenoids from canned tomatoes. Further, we compared the carotenoid response in triglyceride-rich lipoproteins (TRL) after single consumption with the change in fasting plasma carotenoid concentrations after 4 d of daily consumption. In a split plot design, 17 men and women consumed tomatoes which had received minimal additional heating and 16 others consumed extensively additionally heated tomatoes (1 h at 100°C). These tomatoes were not, mildly or severely homogenized. The tomato products were consumed daily (ca. 22 mg/d lycopene) for 4 d. Eleven participants provided postprandial blood samples on the d 1 and all gave fasting blood samples on d 1 and 4. Homogenization enhanced the lycopene response significantly (P < 0.05) both in TRL [mean areas under the curves: 54.9, 72.0 and 88.7 nmol · h/L (SE 11.0) for not, mildly and severely homogenized tomatoes, respectively] and in plasma [mean changes: 0.19, 0.22 and 0.23 µmol/L (SE 0.009), respectively]. Additional heating also tended to enhance the lycopene responses in TRL (P = 0.14) and plasma (P = 0.17). Similar effects to those for lycopene were found for ß-carotene. We conclude that the intactness of the cellular matrix of tomatoes determines the bioavailability of carotenoids and that matrix disruption by mechanical homogenization and/or heat treatment enhances the bioavailability. The carotenoid response in plasma after 4 d intervention can be used to compare the bioavailability of carotenoids from different foods.

KEY WORDS: • carotenoids • lycopene • bioavailability • tomatoes • humans

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