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Supplement

Hormonal Control of Renal and Systemic Glutamine Metabolism^{1 ,2}

Department of Medicine, University of Rochester, Rochester, NY 14642 and ^* Department of Medicine, University of Tubingen, 72076 Tubingen, Germany

³To whom correspondence should be addressed.

Glutamine is the most abundant free amino acid in the human body. Recent studies indicate that it may be an important vehicle for interorgan nitrogen and carbon transport. However, relatively little is known about hormonal factors regulating its metabolism in humans. We review here our recent work on the effects of insulin, glucagon and epinephrine on plasma glutamine kinetics and its conversion to glucose by liver and kidney.

KEY WORDS: • glutamine • gluconeogenesis • kidney • liver • glucose metabolism

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