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(Journal of Nutrition. 2000;130:901S-909S.)
© 2000 The American Society for Nutritional Sciences

Supplement

Glutamic Acid, Twenty Years Later1

S. Garattini

Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy

This review examines progress in understanding the physiologic functions of glutamic acid in the body since the first symposium on glutamic acid physiology and biochemistry was held at the Mario Negri Institute in Milan in 1978. The topics reviewed, although not exhaustive, include the metabolism of glutamic acid, umami taste, the role of glutamic acid as a neurotransmitter, glutamate safety and the development of new drugs resulting from the knowledge of the neurodegeneration induced by high doses of glutamic acid.

KEY WORDS: • glutamic acid • monosodium glutamate • metabolism • central nervous system • neurodegeneration • N-methyl-D-aspartate • {alpha}-amino-3-hydroxy-5-methyl-4-isoxazole propionate • metabotropic receptors • glutamate transporters.






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