![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
*
Biological Science Laboratories, Kao Corporation, Tochigi, 321-3497, Japan;
Department of Biochemistry, Teikyo University School of Medicine, Tokyo, 173-8605, Japan; and
**
Division of Clinical Nutrition, The National Institute of Health and Nutrition, Tokyo, 162-0052, Japan
1To whom correspondence should be addressed.
We examined the effects of the long-term ingestion of dietary diacylglycerols (DG) in a double-blind controlled study of human lipid metabolism. Healthy men (n = 38; aged from 27 to 49 y, body mass index (BMI) ranging from 21.8 to 27.4 kg/m2) completed the study. To accustom the subjects to the test diets prior to the experiment, they were supplied with test diets of triacylglycerol (TG) oil for 4 wk (control period). The test oils (10 g/d) were included in bread, mayonnaise or shortbread and served for the breakfast. The target for total lipid intake was 50 g/d (15 g for breakfast, 15 g for lunch and 20 g for dinner) throughout the study. The subjects were then divided into two groups so that mean BMI and the hepatic fat content, determined by computed tomography, for each group were not different. One group (DG group) consumed test meals containing DG-rich oil (10 g/d) while the other group (TG group) consumed the same meal as during the control period. Ten grams of the DG-rich oil contained 5.5 g 1,3-DG, 2.5 g 1,2-DG and 2 g TG. The actual lipid intake during the study was 43 g/d. Body weight, BMI and waist circumference decreased in both groups at the end of the test period of 16 wk. However, the magnitudes of decreases in these variables were significantly greater in the DG group than in the TG group. Decreases of total fat, visceral fat area and subcutaneous fat area of the abdominal traverse images of computed tomography in the DG group were also significantly greater than those in the TG group. Hepatic fat content decreased significantly in the DG group while no change was observed in the TG group. Serum lipid concentrations (TG, total cholesterol, free fatty acid) and related metabolites (glucose, insulin, total ketone body) did not change significantly in either group. Thus, in contrast to TG, DG apparently suppressed accumulation of fat and possibly reduces the risk of diseases associated with visceral fat obesity.
KEY WORDS: • diacylglycerol • triacylglycerol • humans • visceral fat
This article has been cited by other articles:
|
|
 |
|
  A. Shimotoyodome, D. Fukuoka, J. Suzuki, Y. Fujii, T. Mizuno, S. Meguro, I. Tokimitsu, and T. Hase Coingestion of Acylglycerols Differentially Affects Glucose-Induced Insulin Secretion via Glucose-Dependent Insulinotropic Polypeptide in C57BL/6J Mice Endocrinology, May 1, 2009; 150(5): 2118 - 2126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-H. Chon, Y. X. Zhou, J. L. Dixon, and J. Storch Intestinal Monoacylglycerol Metabolism: DEVELOPMENTAL AND NUTRITIONAL REGULATION OF MONOACYLGLYCEROL LIPASE AND MONOACYLGLYCEROL ACYLTRANSFERASE J. Biol. Chem., November 16, 2007; 282(46): 33346 - 33357. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ota, S. Soga, T. Hase, I. Tokimitsu, and T. Murase Dietary Diacylglycerol Induces the Regression of Atherosclerosis in Rabbits J. Nutr., May 1, 2007; 137(5): 1194 - 1199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Kristensen, H. Jorgensen, and H. Mu Diacylglycerol Oil Does Not Affect Portal Vein Transport of Nonesterified Fatty Acids but Decreases the Postprandial Plasma Lipid Response in Catheterized Pigs J. Nutr., July 1, 2006; 136(7): 1800 - 1805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Bauer, D. Nagaoka, B. Porterpan, K. Bigley, T. Umeda, and K. Otsuji Postprandial Lipolytic Activities, Lipids, and Carbohydrate Metabolism Are Altered in Dogs Fed Diacylglycerol Meals Containing High- and Low-Glycemic-Index Starches J. Nutr., July 1, 2006; 136(7): 1955S - 1957S. [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yamamoto, K. Tomonobu, H. Asakawa, K. Tokunaga, T. Hase, I. Tokimitsu, and N. Yagi Diet Therapy With Diacylglycerol Oil Delays the Progression of Renal Failure in Type 2 Diabetic Patients With Nephropathy Diabetes Care, February 1, 2006; 29(2): 417 - 419. [Full Text] [PDF]
|
|
|
|
 |
|
 M.-P. St-Onge Dietary fats, teas, dairy, and nuts: potential functional foods for weight control? Am. J. Clinical Nutrition, January 1, 2005; 81(1): 7 - 15. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Lo, B. S. Baharin, C. P. Tan, and O. M. Lai Diacylglycerols from Palm Oil Deodoriser Distillate. Part 1 - Synthesis by Lipase-catalysed Esterification Food Science and Technology International, June 1, 2004; 10(3): 149 - 156. [Abstract] [PDF]
|
|
|
|
|
|
M. M. Kamphuis, D. J Mela, and M. S Westerterp-Plantenga Diacylglycerols affect substrate oxidation and appetite in humans Am. J. Clinical Nutrition, May 1, 2003; 77(5): 1133 - 1139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C Maki, M. H Davidson, R. Tsushima, N. Matsuo, I. Tokimitsu, D. M Umporowicz, M. R Dicklin, G. S Foster, K. A Ingram, B. D Anderson, et al. Consumption of diacylglycerol oil as part of a reduced-energy diet enhances loss of body weight and fat in comparison with consumption of a triacylglycerol control oil Am. J. Clinical Nutrition, December 1, 2002; 76(6): 1230 - 1236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Murase, M. Aoki, T. Wakisaka, T. Hase, and I. Tokimitsu Anti-obesity effect of dietary diacylglycerol in C57BL/6J mice: dietary diacylglycerol stimulates intestinal lipid metabolism J. Lipid Res., August 1, 2002; 43(8): 1312 - 1319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yamamoto, H. Asakawa, K. Tokunaga, H. Watanabe, N. Matsuo, I. Tokimitsu, and N. Yagi Long-Term Ingestion of Dietary Diacylglycerol Lowers Serum Triacylglycerol in Type II Diabetic Patients with Hypertriglyceridemia J. Nutr., December 1, 2001; 131(12): 3204 - 3207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Murase, T. Mizuno, T. Omachi, K. Onizawa, Y. Komine, H. Kondo, T. Hase, and I. Tokimitsu Dietary diacylglycerol suppresses high fat and high sucrose diet-induced body fat accumulation in C57BL/6J mice J. Lipid Res., March 1, 2001; 42(3): 372 - 378. [Abstract] [Full Text]
|
|
