QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Metón, I. Articles by Baanante, I. V. Search for Related Content PubMed PubMed Citation Articles by Metón, I. Articles by Baanante, I. V.

---

Research Communication

Liver Insulin-like Growth Factor-I mRNA Is Not Affected by Diet Composition or Ration Size but Shows Diurnal Variations in Regularly-Fed Gilthead Sea Bream (Sparus aurata)¹

Isidoro Metón^*, Anna Caseras^*, Elisabet Cantó^*, Felipe Fernández and Isabel V. Baanante^*2

^* Departament de Bioquímica i Biologia Molecular, Facultat de Farmàcia and Departament d’Ecologia, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain

²To whom correspondence should be addressed.

Nutritional regulation of insulin-like growth factor-I (IGF-I) mRNA was assessed in liver of gilthead sea bream (Sparus aurata). As in mammals, starvation lowered the IGF-I mRNA content, which was recovered by refeeding. However, in contrast to previous observations in rats, neither diet composition nor ration size significantly affected hepatic IGF-I mRNA. Although fish growth depended on the quantity of diet supplied, no relationship was found between growth and liver IGF-I mRNA levels, a fact that challenges the importance, at least in fish, of liver-derived IGF-I on body growth attributed by the classical somatomedin hypothesis. In addition, diurnal modulation of mRNA levels occurred following food intake, suggesting that the intake of food may play a key role in the regulation of the short-term anabolic effects of IGF-I.

KEY WORDS: • insulin-like growth factor-I • dietary nutrients • diurnal variation • Sparus aurata

This article has been cited by other articles:

				Z. Fu, T. Noguchi, and H. Kato Vitamin A Deficiency Reduces Insulin-Like Growth Factor (IGF)-I Gene Expression and Increases IGF-I Receptor and Insulin Receptor Gene Expression in Tissues of Japanese Quail (Coturnix coturnix japonica) J. Nutr., April 1, 2001; 131(4): 1189 - 1194. [Abstract] [Full Text]

				R. B. Eckhardt Genetic Research and Nutritional Individuality J. Nutr., February 1, 2001; 131(2): 336S - 339. [Abstract] [Full Text]