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Supplement

The Administration to Indonesians of Monosodium L-Glutamate in Indonesian Foods: An Assessment of Adverse Reactions in a Randomized Double-Blind, Crossover, Placebo-Controlled Study¹

Department of Pharmacology, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia and ^* Department of Mathematical Sciences, Faculty of Business and Technology, University of Western Sydney, Australia

²To whom correspondence should be addressed.

Monosodium L-glutamate (MSG) has been suggested to cause postprandial symptoms after the ingestion of Chinese or oriental meals. Therefore, we examined whether such symptoms could be elicited in Indonesians ingesting levels of MSG typically found in Indonesian cuisine. Healthy volunteers (n = 52) were treated with capsules of placebo or MSG (1.5 and 3.0 g/person) as part of a standardized Indonesian breakfast. The study used a rigorous, randomized, double-blind, crossover design. The occurrence of symptoms after MSG ingestion did not differ from that after consumption of the placebo.

KEY WORDS: • monosodium glutamate • randomized double-blind challenge • adverse reactions • humans