QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Knudsen, J. Articles by Hansen, J. K. Search for Related Content PubMed PubMed Citation Articles by Knudsen, J. Articles by Hansen, J. K.

---

Supplement

Role of Acyl-CoA Binding Protein in Acyl-CoA Metabolism and Acyl-CoA–Mediated Cell Signaling^{1 ,2}

Institute of Biochemistry, Odense University, DK-5230 Odense M Denmark

³To whom correspondence should be addressed.

Long-chain acyl-CoA esters (LCA) act both as substrates and intermediates in metabolism and as regulators of various intracellular functions. Acyl-CoA binding protein (ACBP) binds LCA with high affinity and is believed to play an important role in intracellular acyl-CoA transport and pool formation and therefore also for the function of LCA as metabolites and regulators of cellular functions . The free concentration of cytosolic LCA is efficiently buffered to low nanomole concentration by ACBP and fatty acid binding protein (FABP). An additional important factor is the activity of acyl-CoA hydrolases. The estimated cellular free LCA concentration is two to four orders of magnitude lower than the concentrations reported to be necessary to regulate most LCA-affected cellular functions. Preliminary evidence indicates that the regulatory effect of LCA might be mediated by the LCA/ACBP complex.

KEY WORDS: • acyl-CoA • fatty acids • metabolism • cell signaling

This article has been cited by other articles:

				S. Yamada, M. Komatsu, Y. Sato, K. Yamauchi, T. Aizawa, and I. Kojima Nutrient Modulation of Palmitoylated 24-Kilodalton Protein in Rat Pancreatic Islets Endocrinology, December 1, 2003; 144(12): 5232 - 5241. [Abstract] [Full Text] [PDF]

				J. Dai, H. Zhu, J. Shi, and G. Woldegiorgis Identification by Mutagenesis of Conserved Arginine and Tryptophan Residues in Rat Liver Carnitine Palmitoyltransferase I Important for Catalytic Activity J. Biol. Chem., July 14, 2000; 275(29): 22020 - 22024. [Abstract] [Full Text] [PDF]