QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Morrison, R. F. Articles by Farmer, S. R. Search for Related Content PubMed PubMed Citation Articles by Morrison, R. F. Articles by Farmer, S. R.

---

Supplement

Hormonal Signaling and Transcriptional Control of Adipocyte Differentiation^{1 ,2}

Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118

³To whom correspondence should be addressed.

Recent advances regarding the biology of adipose tissue have identified the adipocyte as an important mediator in many physiologic and pathologic processes regarding energy metabolism. Consideration for a central role of adipose tissue in the development of obesity, cardiovascular disease and noninsulin-dependent diabetes mellitus has resulted in new incentives toward understanding the complexities of adipocyte differentiation. Current knowledge of this process includes a cascade of transcriptional events that culminate in the expression of peroxisome proliferator–activated receptor- (PPAR) and CCAAT/enhancer binding protein- (C/EBP). These prominent adipogenic transcription factors have been shown to regulate, directly or indirectly, the gene expression necessary for the development of the mature adipocyte. Hormonal and nutritional signaling that impinges on these trans-acting factors provides a molecular link between lipids and lipid-related compounds and the gene expression important for glucose and lipid homeostasis. Knowledge concerning the transcriptional events mediating adipocyte differentiation provides a basis for understanding the physiologic processes associated with adipose tissue as well as for the development of therapeutic interventions in obesity and its related disorders.

KEY WORDS: • energy metabolism • adipose tissue • transcription • gene expression • peroxisome proliferator–activated receptor-

This article has been cited by other articles:

				M. Christian, E. Kiskinis, D. Debevec, G. Leonardsson, R. White, and M. G. Parker RIP140-Targeted Repression of Gene Expression in Adipocytes Mol. Cell. Biol., November 1, 2005; 25(21): 9383 - 9391. [Abstract] [Full Text] [PDF]

				J. E. Kim and J. Chen Regulation of Peroxisome Proliferator-Activated Receptor-{gamma} Activity by Mammalian Target of Rapamycin and Amino Acids in Adipogenesis Diabetes, November 1, 2004; 53(11): 2748 - 2756. [Abstract] [Full Text] [PDF]

				K. E. Davis, M. Moldes, and S. R. Farmer The Forkhead Transcription Factor FoxC2 Inhibits White Adipocyte Differentiation J. Biol. Chem., October 8, 2004; 279(41): 42453 - 42461. [Abstract] [Full Text] [PDF]

				X. Su, D. J. Mancuso, P. E. Bickel, C. M. Jenkins, and R. W. Gross Small Interfering RNA Knockdown of Calcium-independent Phospholipases A2 {beta} or {gamma} Inhibits the Hormone-induced Differentiation of 3T3-L1 Preadipocytes J. Biol. Chem., May 21, 2004; 279(21): 21740 - 21748. [Abstract] [Full Text] [PDF]

				C. L. Varley, J. Stahlschmidt, B. Smith, M. Stower, and J. Southgate Activation of Peroxisome Proliferator-Activated Receptor-{gamma} Reverses Squamous Metaplasia and Induces Transitional Differentiation in Normal Human Urothelial Cells Am. J. Pathol., May 1, 2004; 164(5): 1789 - 1798. [Abstract] [Full Text] [PDF]

				T. Mae, H. Kishida, T. Nishiyama, M. Tsukagawa, E. Konishi, M. Kuroda, Y. Mimaki, Y. Sashida, K. Takahashi, T. Kawada, et al. A Licorice Ethanolic Extract with Peroxisome Proliferator-Activated Receptor-{gamma} Ligand-Binding Activity Affects Diabetes in KK-Ay Mice, Abdominal Obesity in Diet-Induced Obese C57BL Mice and Hypertension in Spontaneously Hypertensive Rats J. Nutr., November 1, 2003; 133(11): 3369 - 3377. [Abstract] [Full Text] [PDF]

				Z. E. Floyd and J. M. Stephens STAT5A Promotes Adipogenesis in Nonprecursor Cells and Associates With the Glucocorticoid Receptor During Adipocyte Differentiation Diabetes, February 1, 2003; 52(2): 308 - 314. [Abstract] [Full Text] [PDF]

				N. G. Patel, J. C. Holder, S. A. Smith, S. Kumar, and M. C. Eggo Differential Regulation of Lipogenesis and Leptin Production by Independent Signaling Pathways and Rosiglitazone During Human Adipocyte Differentiation Diabetes, January 1, 2003; 52(1): 43 - 50. [Abstract] [Full Text] [PDF]

				H. Yan, E. Aziz, G. Shillabeer, A. Wong, D. Shanghavi, A. Kermouni, M. Abdel-Hafez, and D. C. W. Lau Nitric oxide promotes differentiation of rat white preadipocytes in culture J. Lipid Res., December 1, 2002; 43(12): 2123 - 2129. [Abstract] [Full Text] [PDF]

				M. Imamura, T. Inoguchi, S. Ikuyama, S. Taniguchi, K. Kobayashi, N. Nakashima, and H. Nawata ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts Am J Physiol Endocrinol Metab, October 1, 2002; 283(4): E775 - E783. [Abstract] [Full Text] [PDF]

				R. Walczak and P. Tontonoz PPARadigms and PPARadoxes: expanding roles for PPAR{gamma} in the control of lipid metabolism J. Lipid Res., February 1, 2002; 43(2): 177 - 186. [Abstract] [Full Text] [PDF]

				F. M. Gregoire Adipocyte Differentiation: From Fibroblast to Endocrine Cell Experimental Biology and Medicine, December 1, 2001; 226(11): 997 - 1002. [Abstract] [Full Text] [PDF]