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(Journal of Nutrition. 2000;130:3050-3054.)
© 2000 The American Society for Nutritional Sciences

Articles

Secretion of {alpha}-Tocopherol in VLDL Is Decreased by Dietary Protein Insufficiency in Young Growing Rats1

Huey-Mei Shaw2 and Ching-jang Huang3

Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, National Taiwan University, Taipei, Taiwan 106

3To whom correspondence should be addressed.

The concentrations of {alpha}-tocopherol in plasma and most peripheral tissues were shown previously to be low in young growing rats fed a low protein diet. To examine the secretion rates of VLDL {alpha}-tocopherol and triglycerides, and lipoprotein lipase activity, weanling rats were fed a low protein (LP, 8 g/100 g lactalbumin) or a normal protein (NP, 20 g/100 g lactalbumin) diet for 6 wk. The absolute secretion rate of VLDL triglyceride (µmol/h) of the LP group was not significantly different from that of the NP group (P > 0.05), but was significantly higher (P < 0.05) when expressed relative to body weight [µmol/(h · kg)]. The secretion rates of VLDL {alpha}-tocopherol were significantly lower (P < 0.05) in the LP group than in the NP group. The activities of hepatic lipase, lipoprotein lipase and total heparin-releasable lipase in plasma of the LP group were only 50–60% those of the NP group (P < 0.05). The results demonstrated that the secretion rate of VLDL {alpha}-tocopherol and activities of lipases in postheparin plasma were significantly lower in rats fed a low protein diet. Thus, the redistribution of {alpha}-tocopherol from liver to peripheral tissues appears to have been impaired by dietary protein insufficiency.

KEY WORDS: • vitamin E • low protein diet • VLDL secretion rate • lipoprotein lipase • rats






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