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Swiss Federal Station for Animal Production, Posieux, 1725 Switzerland
We evaluated the effects of conjugated linoleic acid (CLA) on growth
performance, tissue fatty acid composition and ex vivo lipogenic enzyme
activity in piglets (n = 40) reared on sows fed
diets supplemented with CLA or linoleic acid (LA). Weaned offspring of
both sow groups were offered either a CLA- or LA-enriched starter
diet for 35 d. The starter diets were formulated to contain 2 g CLA (containing 58.9 g CLA/100 g total fatty acids) or LA per
100 g feed. All piglets were slaughtered at 70 d of age and
tissue samples of the back fat, omental fat and longissimus dorsi were
collected. Irrespective of the dietary fat supplied in the starter
period, piglets reared on the CLA sows had greater final body and warm
carcass weights (P < 0.01), and greater feed
intake (P = 0.02) than piglets reared on the LA
sows. The dietary effect on the fatty acid composition was similar for
the adipose and muscle tissues. Compared with the LA-enriched
diets, CLA increased the level of total saturated fatty acids
(P < 0.05), whereas that of monounsaturated fatty
acids was decreased (P < 0.05). Dietary CLA
increased glucose-6-phosphate dehydrogenase (P < 0.01) and malic enzyme activities (P < 0.06) in
the fat tissues, but did not affect fatty acid synthase activity. The
shift toward a higher deposition of saturated fatty acids and a lower
deposition of monounsaturated fatty acids is the result of
down-regulation of 
9-desaturase activity that was induced by CLA
rather than an altered rate of de novo synthesis.
KEY WORDS: • piglets • conjugated linoleic acids • adipose tissue • lipogenesis
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