QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ichikawa, M. Articles by Miyasaka, K. Search for Related Content PubMed PubMed Citation Articles by Ichikawa, M. Articles by Miyasaka, K.

---

Article

The Diurnal Rhythm of Energy Expenditure Differs between Obese and Glucose-Intolerant Rats and Streptozotocin-Induced Diabetic Rats¹

Mineko Ichikawa^*, Setsuko Kanai, Yuhei Ichimaru^**, Akihiro Funakoshi and Kyoko Miyasaka²

Departments of ^* Nutrition and Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo-173–0015, Japan; ^** Department of Clinical Nutrition, Tokyo Kasei University, Tokyo-173–8602, Japan; and Department of Gastroenterology, National Kyushu Cancer Center, Fukuoka-811–1395, Japan

²To whom correspondence and reprint requests should be addressed.

Otsuka Long Evans Tokushima Fatty (OLETF) rats were developed as a model of noninsulin-dependent diabetes mellitus (NIDDM) with mild obesity. Changes in carcass composition and in the daily profile of energy expenditure were examined before and after manifestation of diabetes (8 and 24 wk, respectively), and compared with the normal control Long Evans Tokushima (LETO) rats and streptozotocin (STZ)-induced diabetic LETO rats. OLETF rats had greater body weights than LETO rats and significantly greater absolute and relative fat weights. A diurnal rhythm of energy expenditure associated with two peaks was observed in LETO rats, but the two peaks were not apparent in OLETF rats at 24 wk of age. A diurnal rhythm associated with one peak was observed in STZ-induced diabetic LETO rats. Energy derived from fat constituted this peak; the pattern of the daily energy expenditure was significantly different from that of either nontreated LETO or OLETF rats at 24 wk of age. NIDDM in OLETF rats at 24 wk of age has only a small role in modification of the diurnal rhythm of energy expenditure, whereas STZ-induced diabetes significantly affected the rhythm.

KEY WORDS: • energy expenditure • insulin resistance • diurnal rhythm • insulin-dependent diabetes mellitus • obesity • rats

This article has been cited by other articles:

				S. Nomoto, M. Ohta, S. Kanai, Y. Yoshida, S. Takiguchi, A. Funakoshi, and K. Miyasaka Absence of the cholecystokinin-A receptor deteriorates homeostasis of body temperature in response to changes in ambient temperature Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2004; 287(3): R556 - R561. [Abstract] [Full Text] [PDF]

				K. Miyasaka, M. Ichikawa, M. Ohta, S. Kanai, Y. Yoshida, M. Masuda, A. Nagata, T. Matsui, T. Noda, S. Takiguchi, et al. Energy Metabolism and Turnover Are Increased in Mice Lacking the Cholecystokinin-B Receptor J. Nutr., April 1, 2002; 132(4): 739 - 741. [Abstract] [Full Text] [PDF]