QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Loï, C. Articles by Louis Sébédio; Search for Related Content PubMed PubMed Citation Articles by Loï, C. Articles by Louis Sébédio;,

---

Article

Incorporation and Metabolism of Dietary Trans Isomers of Linolenic Acid Alter the Fatty Acid Profile of Rat Tissues¹

INRA, Unité de Nutrition Lipidique, BP 86510-21605 Dijon, France and ^* INRA, Laboratoire de Recherche sur les Arômes, 21000 Dijon, France

³To whom correspondence should be addressed .

To study the influence on lipid metabolism and platelet aggregation of the fatty acid isomerization that occurs during heat treatment, weanling rats were fed for 8 wk a diet enriched with 5% isomerized (experimental group) or normal (control group) canola oil. Geometrical isomers of -linolenic acid representing 0.2 g/100 g of the experimental diet were incorporated into liver, platelets, aorta and heart, at the expense of their cis homologue and of 18:2(n-6). The major isomer, 9c,12c,15t-18:3, was also metabolized to 5c,8c,11c,14c,17t-20:5 and to an unknown compound, found in liver, platelets and aorta, which has been identified tentatively as 7c,10c,13c,16c,19t-22:5. The greater 20:4(n-6)/18:2(n-6) ratio in the liver, platelets and heart of the experimental group than the control group indicated an enhancement of desaturation activities. This induced a higher content of long-chain (n-6) fatty acids in the experimental group. Platelet aggregation tended to be slightly higher (P = 0.065) in the experimental group. We conclude that 0.2 g of trans isomers of -linolenic acid per 100 g of diet was sufficient to be incorporated and metabolized, thus altering the fatty acid profile of rat tissues.

KEY WORDS: • dietary trans -linolenic acid • trans 22:5 • platelet aggregation • rats

This article has been cited by other articles:

				N. Acar, J.-M. Chardigny, B. Bonhomme, S. Almanza, M. Doly, and J.-L. Sebedio Long-Term Intake of trans (n-3) Polyunsaturated Fatty Acids Reduces the b-Wave Amplitude of Electroretinograms in Rats J. Nutr., October 1, 2002; 132(10): 3151 - 3154. [Abstract] [Full Text] [PDF]