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Article

Fats Infused Intraduodenally Affect the Postprandial Secretion of the Exocrine Pancreas and the Plasma Concentration of Cholecystokinin but Not of Peptide YY in Growing Pigs¹

Stefan Jakob^*,2, Rainer Mosenthin^*, Romuald Zabielski^**, Catarina Rippe, Maria Sörhede Winzell, Urszula Gacsalyi^**, Daniel Laubitz^,§, Elzbieta Grzesiuk^,§ and Stefan G. Pierzynowski^,

^* Institute of Animal Nutrition (450), Hohenheim University, D-70593 Stuttgart, Germany; Orffa Germany GmbH, D-46483 Wesel, Germany; ^** The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05–110 Jablonna, Poland; Department of Cell and Molecular Biology, Lund University, S-223 62 Lund, Sweden; Department of Animal Physiology, Lund University, S-223 62 Lund, Sweden; Gramineer Int. AB, Ideon beta, S-223 62 Lund, Sweden; and ^§ Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland

²To whom correspondence should be addressed.

In pigs, the spontaneous secretion of the exocrine pancreas and the release of cholecystokinin (CCK) and peptide YY (PYY) after intraduodenal infusion of fully saturated synthetic fats differing in chain length was studied. Growing pigs (n = 6) were prepared with pancreatic duct catheters, duodenal T-cannulas and catheters placed in the jugular vein. The pigs were fed 2 g/100 g body twice daily. Beginning with the morning feeding, a medium-chain triglyceride (MCT: glycerol tricaprylate), a long-chain triglyceride (LCT: glycerol tristearate) or saline was infused at a rate of 0.1 g/100 g body. Pancreatic juice was collected, beginning 1 h preprandially until 3 h postprandially. Blood samples were obtained 15 min preprandially and 15, 45, 90 and 150 min postprandially. The infusion of MCT evoked a change in the trend of the curve for the volume of secretion of pancreatic juice, lipase and colipase concentrations and outputs. The trend of the curve did not change over time for CCK and PYY. Differences between the trends of the curves for the saline and MCT treatment were observed for volume of secretion, protein output, lipase content and output, trypsin and colipase output. Differences in the trends of the curves between MCT and LCT were obtained for the outputs of protein, lipase and colipase. Plasma CCK levels were lower as a result of the MCT treatment compared with the saline and LCT treatments. The results suggest an immediate, distinguished response of the porcine exocrine pancreas to fats differing in chain length.

KEY WORDS: • pigs • pancreatic secretion • fat • cholecystokinin • peptide YY

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