QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Keevil, J. G. Articles by Folts, J. D. Search for Related Content PubMed PubMed Citation Articles by Keevil, J. G. Articles by Folts, J. D.

---

Research Communication

Grape Juice, But Not Orange Juice or Grapefruit Juice, Inhibits Human Platelet Aggregation¹

^* Cardiology Section of Department of Medicine and ^** Department of Animal Sciences, University of Wisconsin, Madison, WI 53792

³To whom correspondence should be addressed.

Coronary artery disease is responsible for much mortality and morbidity around the world. Platelets are involved in atherosclerotic disease development and the reduction of platelet activity by medications reduces the incidence and severity of disease. Red wine and grapes contain polyphenolic compounds, including flavonoids, which can reduce platelet aggregation and have been associated with lower rates of cardiovascular disease. Citrus fruits contain different classes of polyphenolics that may not share the same properties. This study evaluated whether commercial grape, orange and grapefruit juices, taken daily, reduce ex vivo platelet activity. In a randomized cross-over design, ten healthy human subjects (ages 26–58 y, five of each gender) drank 5–7.5 mL/(kg · d) of purple grape juice, orange juice or grapefruit juice for 7–10 d each. Platelet aggregation (whole blood impedance aggregometry, Chronolog Model #590) at baseline was compared to results after consumption of each juice. Drinking purple grape juice for one week reduced the whole blood platelet aggregation response to 1 mg/L of collagen by 77% (from 17.9 ± 2.3 to 4.0 ± 6.8 ohms, P = 0.0002). Orange juice and grapefruit juice had no effect on platelet aggregation. The purple grape juice had approximately three times the total polyphenolic concentration of the citrus juices and was a potent platelet inhibitor in healthy subjects while the citrus juices showed no effect. The platelet inhibitory effect of the flavonoids in grape juice may decrease the risk of coronary thrombosis and myocardial infarction.

KEY WORDS: • platelet aggregation • fruit bioflavonoids • humans

This article has been cited by other articles:

				M. M. Dohadwala and J. A. Vita Grapes and Cardiovascular Disease J. Nutr., September 1, 2009; 139(9): 1788S - 1793S. [Abstract] [Full Text] [PDF]

				J. Lin, K. M. Rexrode, F. Hu, C. M. Albert, C. U. Chae, E. B. Rimm, M. J. Stampfer, and J. E. Manson Dietary Intakes of Flavonols and Flavones and Coronary Heart Disease in US Women Am. J. Epidemiol., June 1, 2007; 165(11): 1305 - 1313. [Abstract] [Full Text] [PDF]

				J. W. Erdman Jr., D. Balentine, L. Arab, G. Beecher, J. T. Dwyer, J. Folts, J. Harnly, P. Hollman, C. L. Keen, G. Mazza, et al. Flavonoids and Heart Health: Proceedings of the ILSI North America Flavonoids Workshop, May 31-June 1, 2005, Washington, DC J. Nutr., March 1, 2007; 137(3): 718S - 737S. [Abstract] [Full Text] [PDF]

				G. Williamson and C. Manach Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies Am. J. Clinical Nutrition, January 1, 2005; 81(1): 243S - 255S. [Abstract] [Full Text] [PDF]

				M. Bohm, S. Rosenkranz, and U. Laufs Alcohol and red wine: impact on cardiovascular risk Nephrol. Dial. Transplant., January 1, 2004; 19(1): 11 - 16. [Full Text] [PDF]

				S. Rajaram The effect of vegetarian diet, plant foods, and phytochemicals on hemostasis and thrombosis Am. J. Clinical Nutrition, September 1, 2003; 78(3): 552S - 558. [Abstract] [Full Text] [PDF]

				J. E. Freedman High-fat diets and cardiovascular disease: Are nutritional supplements useful? J. Am. Coll. Cardiol., May 21, 2003; 41(10): 1750 - 1752. [Full Text] [PDF]

				D. Shanmuganayagam, M. R. Beahm, H. E. Osman, C. G. Krueger, J. D. Reed, and J. D. Folts Grape Seed and Grape Skin Extracts Elicit a Greater Antiplatelet Effect When Used in Combination than When Used Individually in Dogs and Humans J. Nutr., December 1, 2002; 132(12): 3592 - 3598. [Abstract] [Full Text] [PDF]

				C. M. Hasler Functional Foods: Benefits, Concerns and Challenges--A Position Paper from the American Council on Science and Health J. Nutr., December 1, 2002; 132(12): 3772 - 3781. [Abstract] [Full Text] [PDF]

				R. R Holt, S. A Lazarus, M C. Sullards, Q. Y. Zhu, D. D Schramm, J. F Hammerstone, C. G Fraga, H. H Schmitz, and C. L Keen Procyanidin dimer B2 [epicatechin-(4{beta}-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa Am. J. Clinical Nutrition, October 1, 2002; 76(4): 798 - 804. [Abstract] [Full Text] [PDF]

				Y. Wan, J. A Vinson, T. D Etherton, J. Proch, S. A Lazarus, and P. M Kris-Etherton Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans Am. J. Clinical Nutrition, November 1, 2001; 74(5): 596 - 602. [Abstract] [Full Text] [PDF]

				W. H. Briggs, J. D. Folts, H. E. Osman, and I. L. Goldman Administration of Raw Onion Inhibits Platelet-Mediated Thrombosis in Dogs J. Nutr., October 1, 2001; 131(10): 2619 - 2622. [Abstract] [Full Text] [PDF]

				C. L. Keen Chocolate: Food as Medicine/Medicine as Food J. Am. Coll. Nutr., October 1, 2001; 20(90005): 436S - 439. [Abstract] [Full Text]

				J. E. Freedman, C. Parker III, L. Li, J. A. Perlman, B. Frei, V. Ivanov, L. R. Deak, M. D. Iafrati, and J. D. Folts Select Flavonoids and Whole Juice From Purple Grapes Inhibit Platelet Function and Enhance Nitric Oxide Release Circulation, June 12, 2001; 103(23): 2792 - 2798. [Abstract] [Full Text] [PDF]

				S. J. Duffy, J. A. Vita, M. Holbrook, P. L. Swerdloff, and J. F. Keaney Jr Effect of Acute and Chronic Tea Consumption on Platelet Aggregation in Patients With Coronary Artery Disease Arterioscler Thromb Vasc Biol, June 1, 2001; 21(6): 1084 - 1089. [Abstract] [Full Text] [PDF]

				S. D. Wollin and P. J. H. Jones Alcohol, Red Wine and Cardiovascular Disease J. Nutr., May 1, 2001; 131(5): 1401 - 1404. [Abstract] [Full Text]

				D. Rein, T. G. Paglieroni, D. A. Pearson, T. Wun, H. H. Schmitz, R. Gosselin, and C. L. Keen Cocoa and Wine Polyphenols Modulate Platelet Activation and Function J. Nutr., August 1, 2000; 130(8): 2120S - 2126. [Abstract] [Full Text]