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Article

Implanted Tumor Growth Is Suppressed and Survival Is Prolonged in Sixty Percent of Food-Restricted Mice

Departments of Applied Biological Chemistry and ^* Veterinary Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan

¹To whom correspondence should be addressed.

To examine the effect of food restriction on immune functions in the tumor-bearing state, mice were divided into a control group (fed 5.0 g diet/d; 71 kJ/d) and a 60% food-restricted group (fed 3.0 g diet/d; 43 kJ/d) at 8-wk of age, and 4 wk later, L1210 tumor cells were inoculated intradermally. In the food-restricted mice, tumor growth was significantly suppressed, and mean survival time after the tumor inoculation was prolonged (P < 0.05). The plasma concentrations of two antitumor cytokines, interferon- (IFN-) and tumor necrosis factor- (TNF-), were greater in the food-restricted group before tumor inoculation (P < 0.05). Furthermore, the food-restricted mice had significantly higher plasma levels of IFN- and TNF- after tumor inoculation, although the treatment significantly increased these cytokine levels in both groups. Splenic natural killer cell cytotoxicity was also higher in the tumor-bearing food-restricted mice than in controls (P < 0.05). Food-restricted mice have strong antitumor immunity, and as a result, tumor growth is suppressed and survival time is prolonged in these mice.

KEY WORDS: • food restriction • mice • antitumor immunity • interferon- • tumor necrosis factor- • natural killer cells

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