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Improved Growth in Rats on Iodine Deficient Diets

Department of Nutrition, Medical College of the State of South Carolina, Charleston

The subnormal growth of young rats fed the goiter-producing diet of Levine and Remington is improved when a part of the wheat gluten is replaced by 1) purified casein, 2) dried pig liver, or 3) dried brewers yeast. Equal gains were produced with 10% casein, 1% liver or 2% yeast. The addition of 2% liver produced most satisfactory growth.

Purified casein carries sufficient iodine to render it unsuitable for use in goiter-producing diets. Yeast was without effect on degree of goiter but liver aggravated the condition.

A suitable diet for goiter studies on rats is wheat gluten 18, dried pig liver 2, yellow corn meal 78, calcium carbonate 1, sodium chloride 1. On this diet rats reach maturity and produce normal numbers of living young despite almost complete absence of iodine and colloid from the thyroid gland.