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Effect of Diet on the Constancy of the Urinary Nitrogenous Constituents Excreted Daily by Pre-School Children¹

One Figure

Section of Home Economics, Michigan Agricultural Experiment Station, East Lansing, Michigan

1. The amount of total urinary nitrogen, urea, creatinine and, in one experiment, uric acid excreted by six children on constant medium protein diets following a 10- or 12-day preliminary period varied to approximately the same degree as the values for diet nitrogen.

2. Uric acid in one experiment and creatine in both were about twice as variable as diet nitrogen, while ammonia, acidity and amino acid showed more irregularity.

3. The increase in the protein content of the diet caused the values for total nitrogen, urea, ammonia and creatine to be more variable, especially during the first 9 days. Then the figures reached an equilibrium similar to that on the first diet. Therefore, in this study a 9-day preliminary period seemed to be adequate.

4. The change in diet did not seem to influence the variability of the data for acidity, uric acid, amino acid or creatinine.

5. Individual children tended to react in a similar manner both to the constant diet and to the change in the protein content of the diet.

6. When the values were expressed on the basis of kilograms of body weight, the coefficients of variation of the data became larger in all cases. The values for either experiment showed the same tendencies as the data for individuals, but the collective values for the two experiments tended to obscure the fluctuations.

Manuscript received 24 August 1936.