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The Effect of Enteric-Coated Pancreatin on Fat and Protein Digestion of Depancreatized Dogs

Department of Physiology, University of Texas Medical School, Galveston

The effectiveness of several commercial preparations of plain and coated pancreatin on the digestion of ten totally depancreatized dogs, sustained with insulin, was studied. The addition of 3 gm. of pancreatin per 100 gm. of fresh ground meat 1) reduced the quantity of feces by 30 to 60%, 2) increased the elimination time to approximately normal values, 3) reduced the nitrogen loss of the feces by 30 to 60%, but 4) failed to check the loss of fat in the feces. Larger amounts of pancreatin were more effective than small in the digestion of protein, but were no more effective, possibly less effective, than small in the digestion of fat. There appears to be no uniform significant difference between the action of coated and uncoated pancreatin on digestion of fat and protein.

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