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Articles

Delayed Changes in Postprandial Lipid in Young Normolipidemic Men after a Nocturnal Vitamin A Oral Fat Load Test¹

Samy Hadjadj, Jean-Louis Paul^*, Laurent Meyer, Vincent Durlach, Bruno Vergès^**, Olivier Ziegler, Pierre Drouin and Bruno Guerci²

Service de Diabétologie, Nutrition et Maladies Métaboliques & Centre d'Investigation Clinique/INSERM, CHU de Nancy, Hôpital Jeanne d'Arc, 54201 Toul cedex, B.P. 303, France; ^* Laboratoire de Biochimie, Hôpital Broussais AP-HP, 75014 Paris et Faculté de Pharmacie Paris XI, 92296 Chatenay-Malabry, France; Clinique Médicale B U 62, CHU de Reims, 51092 Reims, France; and ^** Clinique Médicale et Endocrinologique, CHU de Dijon, 21000 Dijon, France

²To whom correspondence should be addressed.

The oral fat load tests (OFLT) used to study postprandial lipemia are generally conducted during the day. A nocturnal fat load test could be convenient and physiologically more appropriate. We have therefore compared the lipemic responses of 9 normolipidemic young men to OFLT given at 2200 h (nocturnal) and at 0700 h (diurnal). Triglyceride and retinyl palmitate concentrations were measured for 10 h. Peak plasma concentrations or areas under curves (AUC) for triglyceride after the diurnal and nocturnal tests were not significantly different [2.17 ± 0.78 (diurnal) vs. 2.04 ± 0.87 mmol/L (nocturnal) and 13.12 ± 4.45 (diurnal) vs. 13.74 ± 5.79 mmol/(L · h) (nocturnal)]. Peak plasma concentrations and AUC retinyl palmitate for the two tests were not different [1.71 ± 0.69 (diurnal) vs. 1.42 ± 0.66 mg/L (nocturnal) and 7.17 ± 3.98 (diurnal) vs. 6.63 ± 4.23 mg/(L · h) (nocturnal)]. The diurnal triglyceride peak occurred significantly earlier (4.3 ± 1.2 h) than the nocturnal peak (5.8 ± 1.7 h, P < 0.05). We have developed a model using only three sample time points to predict AUC [triglyceride at 0 h, triglyceride at average peak-time (4 h for diurnal and 6 h for nocturnal tests), and triglyceride at 10 h], thus reducing the number of blood samples. The predicted AUC was well correlated with the total AUC after nocturnal OFLT (r = 0.98, P < 0.0001). The nocturnal test appeared to be well tolerated by the subjects. The three-point simplified protocol may well be suitable for studies on large groups of subjects.

KEY WORDS: • postprandial lipemia • circadian variations • oral fat load test • retinyl palmitate • humans

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