![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Department of Pathology, University of Cincinnati, OH 45267 and * Department of Surgery, Louisiana State University Medical Center, Shreveport, LA 71130
3To whom correspondence should be addressed.
Apolipoprotein (apo) A-IV is a glycoprotein synthesized by the human intestine. In rodents, both the small intestine and the liver secrete apo A-IV; the small intestine, however, is by far the major organ responsible for the circulating apo A-IV. Intestinal apo A-IV synthesis is markedly stimulated by fat absorption and appears not to be mediated by the uptake or reesterification of fatty acids to form triglycerides. Rather, it is the formation of chylomicrons that acts as a signal for the induction of intestinal apo A-IV synthesis. Intestinal apo A-IV synthesis is also enhanced by a factor from the ileum and that factor is probably peptide tyrosine-tyrosine (PYY). The inhibition of food intake by apo A-IV is probably mediated centrally. The stimulation of intestinal synthesis and secretion of apo A-IV by lipid absorption are rapid; thus, apo A-IV likely plays a role in the short-term regulation of food intake. Other evidence suggests that apo A-IV may also be involved in the long-term regulation of food intake and body weight. Chronic ingestion of a high fat diet blunts the intestinal apo A-IV response to lipid feeding and may explain why the chronic ingestion of a high fat diet predisposes both animals and humans to obesity.
KEY WORDS: • apolipoprotein A-IV • chylomicron • intestine • satiety • Sprague-Dawley rats
This article has been cited by other articles:
|
|
 |
|
  D. D'Alessio Intestinal Hormones and Regulation of Satiety: The Case for CCK, GLP-1, PYY, and Apo A-IV JPEN J Parenter Enteral Nutr, September 1, 2008; 32(5): 567 - 568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Weangsripanaval, T. Moriyama, T. Kageura, T. Ogawa, and T. Kawada Dietary Fat and an Exogenous Emulsifier Increase the Gastrointestinal Absorption of a Major Soybean Allergen, Gly m Bd 30K, in Mice J. Nutr., July 1, 2005; 135(7): 1738 - 1744. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Shen, L.-y. Ma, X.-f. Qin, R. Jandacek, R. Sakai, and M. Liu Diurnal changes in intestinal apolipoprotein A-IV and its relation to food intake and corticosterone in rats Am J Physiol Gastrointest Liver Physiol, January 1, 2005; 288(1): G48 - G53. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Liu, L. Shen, Y. Liu, D. Tajima, R. Sakai, S. C. Woods, and P. Tso Diurnal Rhythm of Apolipoprotein A-IV in Rat Hypothalamus and Its Relation to Food Intake and Corticosterone Endocrinology, July 1, 2004; 145(7): 3232 - 3238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Havel Peripheral Signals Conveying Metabolic Information to the Brain: Short-Term and Long-Term Regulation of Food Intake and Energy Homeostasis Experimental Biology and Medicine, December 1, 2001; 226(11): 963 - 977. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. W. Ferrante, M. Thearle, T. Liao, and R. L. Leibel Effects of Leptin Deficiency and Short-Term Repletion on Hepatic Gene Expression in Genetically Obese Mice Diabetes, October 1, 2001; 50(10): 2268 - 2278. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. Koch, N. Donarski, K. Goetze, M. Kreckel, H.-J. Stuerenburg, C. Buhmann, and U. Beisiegel Characterization of four lipoprotein classes in human cerebrospinal fluid J. Lipid Res., July 1, 2001; 42(7): 1143 - 1151. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Kalogeris and R. G. Painter Adaptation of intestinal production of apolipoprotein A-IV during chronic feeding of lipid Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1155 - R1161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Fournier, V. Atger, J.-L. Paul, M. Sturm, N. Duverger, G. H. Rothblat, and N. Moatti Human ApoA-IV Overexpression in Transgenic Mice Induces cAMP-Stimulated Cholesterol Efflux From J774 Macrophages to Whole Serum Arterioscler. Thromb. Vasc. Biol., May 1, 2000; 20(5): 1283 - 1292. [Abstract] [Full Text] [PDF]
|
|
