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(Journal of Nutrition. 1999;129:1251-1260.)
© 1999 The American Society for Nutritional Sciences


Articles

A Delicate Balance: Homeostatic Control of Copper Uptake and Distribution1

Maria M. O. Peña, Jaekwon Lee and Dennis J. Thiele2

Department of Biological Chemistry, The University of Michigan Medical School, Ann Arbor, MI 48109-0606

2To whom correspondence should be addressed

The cellular uptake and intracellular distribution of the essential but highly toxic nutrient, copper, is a precisely orchestrated process. Copper homeostasis is coordinated by several proteins to ensure that it is delivered to specific subcellular compartments and copper-requiring proteins without releasing free copper ions that will cause damage to cellular components. Genetic studies in prokaryotic organisms and yeast have identified membrane-associated proteins that mediate the uptake or export of copper from cells. Within cells, small cytosolic proteins, called copper chaperones, have been identified that bind copper ions and deliver them to specific compartments and copper-requiring proteins. The identification of mammalian homologues of these proteins reveal a remarkable structural and functional conservation of copper metabolism between bacteria, yeast and humans. Furthermore, studies on the function and localization of the products of the Menkes and Wilson's disease genes, which are defective in patients afflicted with these diseases, have provided valuable insight into the mechanisms of copper balance and their role in maintaining appropriate copper distribution in mammals.


KEY WORDS: • copper • transport • distribution • Menkes • Wilson's disease • homeostatic regulation




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[Abstract] [Full Text] [PDF]


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D. J. Adle, D. Sinani, H. Kim, and J. Lee
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J. Biol. Chem., January 12, 2007; 282(2): 947 - 955.
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Home page
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[Abstract] [Full Text] [PDF]


Home page
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Intracellular Copper Transport in Mammals
J. Nutr., May 1, 2004; 134(5): 1003 - 1006.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
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[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
J. M. De Freitas, J. H. Kim, H. Poynton, T. Su, H. Wintz, T. Fox, P. Holman, A. Loguinov, S. Keles, M. van der Laan, et al.
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J. Biol. Chem., February 6, 2004; 279(6): 4450 - 4458.
[Abstract] [Full Text] [PDF]


Home page
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Eukaryot. Cell, February 1, 2004; 3(1): 1 - 13.
[Full Text] [PDF]


Home page
J. Biol. Chem.Home page
L. Banci, I. Bertini, S. Ciofi-Baffoni, L. Gonnelli, and X.-C. Su
Structural Basis for the Function of the N-terminal Domain of the ATPase CopA from Bacillus subtilis
J. Biol. Chem., December 12, 2003; 278(50): 50506 - 50513.
[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
H. Zhou, K. M. Cadigan, and D. J. Thiele
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J. Biol. Chem., November 28, 2003; 278(48): 48210 - 48218.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
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J. Biol. Chem., November 14, 2003; 278(46): 45999 - 46006.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
H. Kim and R. L. Macdonald
An N-Terminal Histidine Is the Primary Determinant of {alpha} Subunit-Dependent Cu2+ Sensitivity of {alpha}{beta}3{gamma}2L GABAA Receptors
Mol. Pharmacol., November 1, 2003; 64(5): 1145 - 1152.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
T. Y. Tao, F. Liu, L. Klomp, C. Wijmenga, and J. D. Gitlin
The Copper Toxicosis Gene Product Murr1 Directly Interacts with the Wilson Disease Protein
J. Biol. Chem., October 24, 2003; 278(43): 41593 - 41596.
[Abstract] [Full Text] [PDF]


Home page
MicrobiologyHome page
A. Uldschmid, R. Dombi, and K. Marbach
Identification and functional expression of ctaA, a P-type ATPase gene involved in copper trafficking in Trametes versicolor
Microbiology, August 1, 2003; 149(8): 2039 - 2048.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
D. Strausak, M. K. Howie, S. D. Firth, A. Schlicksupp, R. Pipkorn, G. Multhaup, and J. F. B. Mercer
Kinetic Analysis of the Interaction of the Copper Chaperone Atox1 with the Metal Binding Sites of the Menkes Protein
J. Biol. Chem., May 30, 2003; 278(23): 20821 - 20827.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Gastrointest. Liver Physiol.Home page
N. R. Zerounian, C. Redekosky, R. Malpe, and M. C. Linder
Regulation of copper absorption by copper availability in the Caco-2 cell intestinal model
Am J Physiol Gastrointest Liver Physiol, May 1, 2003; 284(5): G739 - G747.
[Abstract] [Full Text] [PDF]


Home page
J. Nutr.Home page
J. F. B. Mercer and R. M. Llanos
Molecular and Cellular Aspects of Copper Transport in Developing Mammals
J. Nutr., May 1, 2003; 133(5): 1481S - 1484.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
J. Beaudoin, A. Mercier, R. Langlois, and S. Labbe
The Schizosaccharomyces pombe Cuf1 Is Composed of Functional Modules from Two Distinct Classes of Copper Metalloregulatory Transcription Factors
J. Biol. Chem., April 11, 2003; 278(16): 14565 - 14577.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
M. J. Petris, K. Smith, J. Lee, and D. J. Thiele
Copper-stimulated Endocytosis and Degradation of the Human Copper Transporter, hCtr1
J. Biol. Chem., March 7, 2003; 278(11): 9639 - 9646.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
I. Hamza, J. Prohaska, and J. D. Gitlin
Essential role for Atox1 in the copper-mediated intracellular trafficking of the Menkes ATPase
PNAS, February 4, 2003; 100(3): 1215 - 1220.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
T. C. Steveson, G. D. Ciccotosto, X.-M. Ma, G. P. Mueller, R. E. Mains, and B. A. Eipper
Menkes Protein Contributes to the Function of Peptidylglycine {alpha}-Amidating Monooxygenase
Endocrinology, January 1, 2003; 144(1): 188 - 200.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
D. R. Bellemare, L. Shaner, K. A. Morano, J. Beaudoin, R. Langlois, and S. Labbe
Ctr6, a Vacuolar Membrane Copper Transporter in Schizosaccharomyces pombe
J. Biol. Chem., November 22, 2002; 277(48): 46676 - 46686.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
K. Katano, A. Kondo, R. Safaei, A. Holzer, G. Samimi, M. Mishima, Y.-M. Kuo, M. Rochdi, and S. B. Howell
Acquisition of Resistance to Cisplatin Is Accompanied by Changes in the Cellular Pharmacology of Copper
Cancer Res., November 15, 2002; 62(22): 6559 - 6565.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
X. Lin, T. Okuda, A. Holzer, and S. B. Howell
The Copper Transporter CTR1 Regulates Cisplatin Uptake in Saccharomyces cerevisiae
Mol. Pharmacol., November 1, 2002; 62(5): 1154 - 1159.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
J. Lee, M. J. Petris, and D. J. Thiele
Characterization of Mouse Embryonic Cells Deficient in the Ctr1 High Affinity Copper Transporter. IDENTIFICATION OF A Ctr1-INDEPENDENT COPPER TRANSPORT SYSTEM
J. Biol. Chem., October 18, 2002; 277(43): 40253 - 40259.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
J. F. Eisses and J. H. Kaplan
Molecular Characterization of hCTR1, the Human Copper Uptake Protein
J. Biol. Chem., August 2, 2002; 277(32): 29162 - 29171.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
S. Puig, J. Lee, M. Lau, and D. J. Thiele
Biochemical and Genetic Analyses of Yeast and Human High Affinity Copper Transporters Suggest a Conserved Mechanism for Copper Uptake
J. Biol. Chem., July 12, 2002; 277(29): 26021 - 26030.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
J. Yonkovich, R. McKenndry, X. Shi, and Z. Zhu
Copper Ion-sensing Transcription Factor Mac1p Post-translationally Controls the Degradation of Its Target Gene Product Ctr1p
J. Biol. Chem., June 28, 2002; 277(27): 23981 - 23984.
[Abstract] [Full Text] [PDF]


Home page
Genome ResHome page
F. Arnesano, L. Banci, I. Bertini, S. Ciofi-Baffoni, E. Molteni, D. L. Huffman, and T. V. O'Halloran
Metallochaperones and Metal-Transporting ATPases: A Comparative Analysis of Sequences and Structures
Genome Res., February 1, 2002; 12(2): 255 - 271.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
J. Lee, M. M. O. Pena, Y. Nose, and D. J. Thiele
Biochemical Characterization of the Human Copper Transporter Ctr1
J. Biol. Chem., February 1, 2002; 277(6): 4380 - 4387.
[Abstract] [Full Text] [PDF]


Home page
J. Exp. Biol.Home page
C. Kamunde, M. Grosell, D. Higgs, and C. M. Wood
Copper metabolism in actively growing rainbow trout (Oncorhynchus mykiss): interactions between dietary and waterborne copper uptake
J. Exp. Biol., January 15, 2002; 205(2): 279 - 290.
[Abstract] [Full Text] [PDF]


Home page
Hum Mol GenetHome page
B. van de Sluis, J. Rothuizen, P. L. Pearson, B. A. van Oost, and C. Wijmenga
Identification of a new copper metabolism gene by positional cloning in a purebred dog population
Hum. Mol. Genet., January 1, 2002; 11(2): 165 - 173.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
Z. H. Lu and M. Solioz
Copper-induced Proteolysis of the CopZ Copper Chaperone of Enterococcus hirae
J. Biol. Chem., December 14, 2001; 276(51): 47822 - 47827.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
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Manganese Superoxide Dismutase in Saccharomyces cerevisiae Acquires Its Metal Co-factor through a Pathway Involving the Nramp Metal Transporter, Smf2p
J. Biol. Chem., December 7, 2001; 276(50): 47556 - 47562.
[Abstract] [Full Text] [PDF]