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Human Nutrition and Metabolism

(n-3) Fatty Acid Supplementation in Moderately Hypertriglyceridemic Adults Changes Postprandial Lipid and Apolipoprotein B Responses to a Standardized Test Meal¹

Lesley F. Tinker^*,,3, Elizabeth J Parks, Stephen R. Behr^**, Barbara O. Schneeman^*, and Paul A. Davis²

^* Division of Clinical Nutrition and Metabolism, Department of Internal Medicine, School of Medicine and Department of Nutrition, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616 and ^** Medical Nutrition Research and Development, Ross Products Division of Abbott Laboratories, Columbus, OH 43215

²To whom correspondence should be addressed.

The effects of (n-3) fatty acids on the postprandial state were investigated by monitoring the alimentary responses to identical test meals fed to adults [n = 11; fasting triacylglycerol (TG) 2.55 ± 0.24 mmol/L; mean ± SEM] after a self-selected diet baseline period (BLP) and then after a 6-wk (n-3) fatty acid period (FOP) [~5.2 g (n-3) fatty acids] and a 6-wk control oil period (COP) administered in random order. Samples were drawn immediately prior to the test meal (time 0) and then hourly from 2 to 6 h postmeal. Postprandial plasma triacylglycerol (TG) and TG-rich lipoprotein (TRL) TG apo B48, and B100 absolute concentrations were significantly lower after FOP than after COP or BLP, while plasma cholesterol was unchanged. Normalizing the results as increments over time 0 eliminated the diet effect on all but plasma TG. Time remained a significant effect for plasma TG, TRL TG, and TRL TC. Finally, only absolute TRL B48 and absolute and incremental plasma TG concentrations displayed significant time-diet interactions. These results suggest that postprandial TRL apo B reductions are likely caused by (n-3) fatty acid suppression of both hepatic and intestinal apoB secretion/synthesis. Altered TRL metabolism, i.e. changes in postprandial TG, cholesterol, apo B48, and increase in LDL particle size, may represent an additional mechanism for the reduced heart disease risk associated with fish [(n-3) fatty acid] consumption.

KEY WORDS: • humans • (n-3) fatty acids • apolipoprotein B • triacylglycerol rich lipoproteins • postprandial lipemia

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