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Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611
3To whom correspondence and reprint requests should be addressed.
Folate functions in multiple coenzyme forms in acceptance, redox processing and
transfer of one-carbon units, including nucleotides and certain amino
acids. Folate-requiring metabolic processes are influenced by folate
intake, intake of other essential nutrients, including vitamins B-12
and B-6, and at least one common genetic polymorphism. Estimates of
folate requirements have been based on intakes associated with
maintenance of normal plasma and erythrocyte folate concentrations and
functional tests that reflect abnormalities in folate-dependent
reactions. Dietary Reference Intakes for folate that have been
developed recently are based primarily on metabolic studies in which
erythrocyte folate concentration was considered the major indicator of
adequacy. For adults 
19 y, the Recommended Dietary Allowance (RDA) is
400 µg/d of dietary folate equivalents (DFE); for
lactating and pregnant women, the RDAs include an additional 100 and
200 µg of DFE/d, respectively.
KEY WORDS: • folate • one-carbon metabolism • requirements • dietary reference intakes
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