QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hecht, S. S. Search for Related Content PubMed PubMed Citation Articles by Hecht, S. S.

---

Supplement

Chemoprevention of Cancer by Isothiocyanates, Modifiers of Carcinogen Metabolism

University of Minnesota Cancer Center, Minneapolis, MN 55455

Substantial quantities of isothiocyanates are released upon consumption of normal amounts of a number of cruciferous vegetables. Some of these naturally occurring isothiocyanates such as phenethyl isothiocyanate (PEITC), benzyl isothiocyanate (BITC) and sulforaphane are effective inhibitors of cancer induction in rodents treated with carcinogens. A large amount of data demonstrate that isothiocyanates act as cancer chemopreventive agents by favorably modifying carcinogen metabolism via inhibition of Phase 1 enzymes and/or induction of Phase 2 enzymes. These effects are quite specific, depending on the structure of the isothiocyanate and carcinogen. One of the most thoroughly studied examples of isothiocyanate inhibition of rodent carcinogenesis is inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis by PEITC. This occurs because PEITC blocks the metabolic activation of NNK, resulting in increased urinary excretion of detoxified metabolites. Similar effects on NNK metabolism have been observed in smokers who consumed watercress, a source of PEITC. On the basis of these observations and knowledge of the carcinogenic constituents of cigarette smoke, a strategy for chemoprevention of lung cancer can be developed.

KEY WORDS: • chemoprevention • phenethyl isothiocyanate • 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone • isothiocyanates • watercress

This article has been cited by other articles:

				F. D'Agostini, L. Mastracci, A. Izzotti, R. Balansky, T. M. Pennisi, V. E. Steele, and S. De Flora Modulation by Phenethyl Isothiocyanate and Budesonide of Molecular and Histopathologic Alterations Induced by Environmental Cigarette Smoke in Mice Cancer Prevention Research, June 1, 2009; 2(6): 546 - 556. [Abstract] [Full Text] [PDF]

				K. A. Moy, J.-M. Yuan, F.-L. Chung, D. Van Den Berg, R. Wang, Y.-T. Gao, and M. C. Yu Urinary Total Isothiocyanates and Colorectal Cancer: A Prospective Study of Men in Shanghai, China Cancer Epidemiol. Biomarkers Prev., June 1, 2008; 17(6): 1354 - 1359. [Abstract] [Full Text] [PDF]

				L. Kopelovich, J. R. Fay, C. C. Sigman, and J. A. Crowell The Mammalian Target of Rapamycin Pathway as a Potential Target for Cancer Chemoprevention Cancer Epidemiol. Biomarkers Prev., July 1, 2007; 16(7): 1330 - 1340. [Abstract] [Full Text] [PDF]

				S. J. Thomson, K. K. Brown, J. M. Pullar, and M. B. Hampton Phenethyl Isothiocyanate Triggers Apoptosis in Jurkat Cells Made Resistant by the Overexpression of Bcl-2. Cancer Res., July 1, 2006; 66(13): 6772 - 6777. [Abstract] [Full Text] [PDF]

				M. J. Tijhuis, P. A. Wark, J. M.M.J.G. Aarts, M. H.P.W. Visker, F. M. Nagengast, F. J. Kok, and E. Kampman GSTP1 and GSTA1 Polymorphisms Interact with Cruciferous Vegetable Intake in Colorectal Adenoma Risk Cancer Epidemiol. Biomarkers Prev., December 1, 2005; 14(12): 2943 - 2951. [Abstract] [Full Text] [PDF]

				L. Tang and Y. Zhang Dietary Isothiocyanates Inhibit the Growth of Human Bladder Carcinoma Cells J. Nutr., August 1, 2004; 134(8): 2004 - 2010. [Abstract] [Full Text] [PDF]