QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Setchell, K. D. R. Articles by Cassidy, A. Search for Related Content PubMed PubMed Citation Articles by Setchell, K. D. R. Articles by Cassidy, A.

---

Supplement

Dietary Isoflavones: Biological Effects and Relevance to Human Health¹

Clinical Mass Spectrometry, Children's Hospital Medical Center, Cincinnati, Ohio 45229 and ^* School of Biological Sciences, University of Surrey GU2 5XH

Substantial evidence indicates that diets high in plant-based foods may explain the epidemiologic variance of many hormone-dependent diseases that are a major cause of mortality and morbidity in Western populations. There is now an increased awareness that plants contain many phytoprotectants. Lignans and isoflavones represent two of the main classes of phytoestrogens of current interest in clinical nutrition. Although ubiquitous in their occurrence in the plant kingdom, these bioactive nonnutrients are found in particularly high concentrations in flaxseeds and soybeans and have been found to have a wide range of hormonal and nonhormonal activities that serve to provide plausible mechanisms for the potential health benefits of diets rich in phytoestrogens. Data from animal and in vitro studies provide convincing evidence for the potential of phytoestrogens in influencing hormone-dependent states; although the clinical application of diets rich in these estrogen mimics is in its infancy, data from preliminary studies suggest beneficial effects of importance to health. This review focuses on the more recent studies pertinent to this field and includes, where appropriate, the landmark and historical literature that has led to the exponential increase in interest in phytoestrogens from a clinical nutrition perspective.

KEY WORDS: • phytoestrogens • isoflavones • genistein • hormones • cancer • cardiovascular disease • bone

This article has been cited by other articles:

				V. V. Lozovaya, A. V. Lygin, A. V. Ulanov, R. L. Nelson, J. Dayde, and J. M. Widholm Effect of Temperature and Soil Moisture Status during Seed Development on Soybean Seed Isoflavone Concentration and Composition Crop Sci., August 26, 2005; 45(5): 1934 - 1940. [Abstract] [Full Text] [PDF]

				I. Woclawek-Potocka, T. J. Acosta, A. Korzekwa, M. M. Bah, M. Shibaya, K. Okuda, and D. J. Skarzynski Phytoestrogens Modulate Prostaglandin Production in Bovine Endometrium: Cell Type Specificity and Intracellular Mechanisms Experimental Biology and Medicine, May 1, 2005; 230(5): 326 - 333. [Abstract] [Full Text] [PDF]

				I. Woclawek-Potocka, M. M. Bah, A. Korzekwa, M. K. Piskula, W. Wiczkowski, A. Depta, and D. J. Skarzynski Soybean-Derived Phytoestrogens Regulate Prostaglandin Secretion in Endometrium During Cattle Estrous Cycle and Early Pregnancy Experimental Biology and Medicine, March 1, 2005; 230(3): 189 - 199. [Abstract] [Full Text] [PDF]

				E. B. Gold, G. Block, S. Crawford, L. Lachance, G. FitzGerald, H. Miracle, and S. Sherman Lifestyle and Demographic Factors in Relation to Vasomotor Symptoms: Baseline Results from the Study of Women's Health Across the Nation Am. J. Epidemiol., June 15, 2004; 159(12): 1189 - 1199. [Abstract] [Full Text] [PDF]

				T. D. Lund, D. J. Munson, M. E. Haldy, K. D.R. Setchell, E. D. Lephart, and R. J. Handa Equol Is a Novel Anti-Androgen that Inhibits Prostate Growth and Hormone Feedback Biol Reprod, April 1, 2004; 70(4): 1188 - 1195. [Abstract] [Full Text] [PDF]

				C. T. Fulton and J. N. Stallone Sexual dimorphism in prostanoid-potentiated vascular contraction: roles of endothelium and ovarian steroids Am J Physiol Heart Circ Physiol, November 1, 2002; 283(5): H2062 - H2073. [Abstract] [Full Text] [PDF]

				C.-J. Liu, J. W. Blount, C. L. Steele, and R. A. Dixon Bottlenecks for metabolic engineering of isoflavone glycoconjugates in Arabidopsis PNAS, October 29, 2002; 99(22): 14578 - 14583. [Abstract] [Full Text] [PDF]

				K. M. Robertson, L. O'Donnell, E. R. Simpson, and M. E. E. Jones The Phenotype of the Aromatase Knockout Mouse Reveals Dietary Phytoestrogens Impact Significantly on Testis Function Endocrinology, August 1, 2002; 143(8): 2913 - 2921. [Abstract] [Full Text] [PDF]

				E. A. Lucas, R. D. Wild, L. J. Hammond, D. A. Khalil, S. Juma, B. P. Daggy, B. J. Stoecker, and B. H. Arjmandi Flaxseed Improves Lipid Profile without Altering Biomarkers of Bone Metabolism in Postmenopausal Women J. Clin. Endocrinol. Metab., April 1, 2002; 87(4): 1527 - 1532. [Abstract] [Full Text] [PDF]

				B. L. Strom, R. Schinnar, E. E. Ziegler, K. T. Barnhart, M. D. Sammel, G. A. Macones, V. A. Stallings, J. M. Drulis, S. E. Nelson, and S. A. Hanson Exposure to Soy-Based Formula in Infancy and Endocrinological and Reproductive Outcomes in Young Adulthood JAMA, August 15, 2001; 286(7): 807 - 814. [Abstract] [Full Text] [PDF]

				J. W. Lampe, H. E. Skor, S. Li, K. Wähälä, W. N. Howald, and C. Chen Wheat Bran and Soy Protein Feeding Do Not Alter Urinary Excretion of the Isoflavan Equol in Premenopausal Women J. Nutr., March 1, 2001; 131(3): 740 - 744. [Abstract] [Full Text]