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Departments of a Epidemiology and b Nutrition, Harvard School of Public Health, c The Harvard Center for Cancer Prevention, and d Channing Laboratory, Department of Medicine, Brigham and Woman's Hospital, Harvard Medical School, Boston, MA 02115
Our studies on interactions of a folate-metabolizing gene polymorphism
and dietary intake in colorectal tumorigenesis demonstrate the
potential importance of studying interactions between genotype and
environmental exposure in relation to cancer risk. We observed an
inverse association of a polymorphism (667C 
T, ala
val) in the methylenetetrahydrofolate reductase (MTHFR) gene
with colorectal cancer but not with colorectal adenomas. The inverse
association of methionine and adverse association of alcohol with
colorectal cancer were stronger among val/val individuals.
These interactions were not present in studies of colorectal adenomas.
Our studies illustrate that studying gene-environment interactions in
relation to cancer can be of importance in clarifying cancer etiology
as well as pointing to preventive dietary modifications.
KEY WORDS: • MTHFR polymorphism • colorectal cancer • colorectal adenomas • methyl diet
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