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(Journal of Nutrition. 1999;129:477-484.)
© 1999 The American Society for Nutritional Sciences

Supplement

Molecular Biology of Biotin Attachment to Proteins

Anne Chapman-Smith2 and John E. Cronan Jr 1

Departments of Microbiology and Biochemistry, University of Illinois, Urbana, Illinois 61801

Enzymatic attachment of biotin to proteins requires the interaction of a distinct domain of the acceptor protein (the "biotin domain") with the enzyme, biotin protein ligase, that catalyzes this essential and rare post-translational modification. Both biotin domains and biotin protein ligases are very strongly conserved throughout biology. This review concerns the protein structures and mechanisms involved in the covalent attachment of biotin to proteins.

KEY WORDS: • biotin • domain • acceptor • ligase • post-translational




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