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Supplement

The LDL Receptor Gene Family, Apolipoprotein B and Cholesterol in Embryonic Development

Department of Molecular Genetics, UT Southwestern, Dallas, TX 75235 and ^a Gladstone Institute of Cardiovascular Disease and ^b Department of Medicine, University of California, San Francisco, CA 94141–9100

In recent years, a number of genes that are involved in cholesterol synthesis, its systemic or intercellular transport or lipid metabolism in general have been found to play important roles during embryonic development. In this article, we present a brief overview of these genes, their molecular functions as we understand them to date and our current interpretation of possible mechanisms by which genetic deficiency states might affect the development of the embryo, in particular the formation of the central nervous system.

KEY WORDS: • LRP • exencephaly • central nervous system • hedgehog • scavenger receptor class B type I

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