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Assembly of Very Low Density Lipoprotein: A Two-Step Process of Apolipoprotein B Core Lipidation

Department of Medical Biochemistry and ^a The Wallenberg Laboratory, Göteborg University, Göteborg, Sweden

The liver plays a primary role in lipid metabolism. Important functions include the synthesis and incorporation of hydrophobic lipids, triacylglycerols and cholesteryl esters into the core of water-miscible particles called lipoproteins and the secretion of these particles into the circulation for transport to distant tissues. In this article, we present a brief overview of one aspect of the assembly process of very low density lipoproteins, namely, possible mechanisms for combining core lipids with apolipoprotein B. This is a complex process in which apolipoprotein B interacts with core lipids to form very low density lipoproteins by a two-step process that can be dissociated biochemically.

KEY WORDS: • apolipoproteinB-HDL • Brefeldin A • hepatoma cells • microsomal triglyceride transfer protein • secretion

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