QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rahman, M. M. Articles by Fuchs, G. J. Search for Related Content PubMed PubMed Citation Articles by Rahman, M. M. Articles by Fuchs, G. J.

---

Article

Simultaneous Vitamin A Administration at Routine Immunization Contact Enhances Antibody Response to Diphtheria Vaccine in Infants Younger than Six Months¹

M. M. Rahman^*2, D. Mahalanabis^*,, S. Hossain^*, M. A. Wahed^*, J. O. Alvarez^**, G. R. Siber, Claudette Thompson, M. Santosham and G. J. Fuchs^*

^* ICDDR,B: Centre for Health and Population Research, Dhaka 1000, Bangladesh; Society for Applied Research, Calcutta, India; ^** University of Alabama at Birmingham, Birmingham, AL; Massachusettes Public Health Biologic Laboratories, Boston, MA; and John Hopkins University, Baltimore, MD

²To whom correspondence should be addressed.

A randomized, double-blind, placebo-controlled trial was conducted to evaluate the effect of simultaneous vitamin A supplementation and diphtheria, pertussis and tetanus (DPT) vaccination on the antibody levels. Infants aged 6–17 wk (n = 56) were randomly given 15 mg oral vitamin A or placebo at the time of their DPT immunization. Three such doses were given at monthly intervals. Immunoglobulin (Ig) G antibodies to diphtheria, pertussis and tetanus were assayed on enrollment and 1 mo after the third dose. Baseline antibody concentrations to diphtheria, pertussis and tetanus did not differ between the vitamin A–supplemented and placebo-treated groups. The postdose antibody to diphtheria level was significantly greater in the vitamin A than in the placebo-treated group. The geometric mean ± SEM antibody levels (mg/L) were 22.9 ± 1.2 and 11.0 ± 1.3 in the vitamin A and placebo groups, respectively (P = 0.029). The postsupplementation concentrations of antibodies to pertussis and tetanus did not differ between the two groups. These results suggest that antibody response to diphtheria vaccination was potentiated by simultaneous vitamin A administration and DPT immunization.

KEY WORDS: • infants • vitamin A • diphtheria • pertussis • tetanus • antibody • immunization

This article has been cited by other articles:

				M. Savy, K. Edmond, P. E. M. Fine, A. Hall, B. J. Hennig, S. E. Moore, K. Mulholland, U. Schaible, and A. M. Prentice Landscape Analysis of Interactions between Nutrition and Vaccine Responses in Children J. Nutr., November 1, 2009; 139(11): 2154S - 2218S. [Abstract] [Full Text] [PDF]

				S. M. Ahmad, M. J. Haskell, R. Raqib, and C. B. Stephensen Men with Low Vitamin A Stores Respond Adequately to Primary Yellow Fever and Secondary Tetanus Toxoid Vaccination J. Nutr., November 1, 2008; 138(11): 2276 - 2283. [Abstract] [Full Text] [PDF]

				S. Sankaranarayanan, Y. Ma, M. C. Bryson, N.-q. Li, and A. C. Ross Neonatal-Age Treatment with Vitamin A Delays Postweaning Vitamin A Deficiency and Increases the Antibody Response to T-cell Dependent Antigens in Young Adult Rats Fed a Vitamin A-Deficient Diet J. Nutr., May 1, 2007; 137(5): 1229 - 1235. [Abstract] [Full Text] [PDF]

				S. Newton, S. Owusu-Agyei, W. Ampofo, C. Zandoh, M. Adjuik, G. Adjei, S. Tchum, S. Filteau, and B. R. Kirkwood Vitamin A Supplementation Enhances Infants' Immune Responses to Hepatitis B Vaccine but Does Not Affect Responses to Haemophilus influenzae Type b Vaccine J. Nutr., May 1, 2007; 137(5): 1272 - 1277. [Abstract] [Full Text] [PDF]

				Y. Ma and A. C. Ross The anti-tetanus immune response of neonatal mice is augmented by retinoic acid combined with polyriboinosinic:polyribocytidylic acid PNAS, September 20, 2005; 102(38): 13556 - 13561. [Abstract] [Full Text] [PDF]

				E. Villamor and W. W. Fawzi Effects of Vitamin A Supplementation on Immune Responses and Correlation with Clinical Outcomes Clin. Microbiol. Rev., July 1, 2005; 18(3): 446 - 464. [Abstract] [Full Text] [PDF]

				Y. Ma, Q. Chen, and A. C. Ross Retinoic Acid and Polyriboinosinic:Polyribocytidylic Acid Stimulate Robust Anti-Tetanus Antibody Production while Differentially Regulating Type 1/Type 2 Cytokines and Lymphocyte Populations J. Immunol., June 15, 2005; 174(12): 7961 - 7969. [Abstract] [Full Text] [PDF]

				N. Engedal, A. Ertesvag, and H. K. Blomhoff Survival of activated human T lymphocytes is promoted by retinoic acid via induction of IL-2 Int. Immunol., March 1, 2004; 16(3): 443 - 453. [Abstract] [Full Text] [PDF]