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Article

Blood Concentration of Coenzyme Q₁₀ Increases in Rats When Esterified Forms Are Administered¹

Mikael Turunen^*2, Eeva-Liisa Appelkvist, Pavel Sindelar^** and Gustav Dallner^*

^* Department of Biochemistry, Stockholm University, S-106 91 Stockholm, Sweden and Clinical Research Center and ^** Department of Molecular Medicine, Karolinska Institutet, S-171 76, Stockholm, Sweden

²To whom correspondence should be addressed.

Coenzyme Q levels decrease during aging in most tissues and in the target organs of a number of diseases. The uptake of this lipid into the blood and other tissues was investigated in 6-wk-old male Sprague-Dawley rats after 3 wk of dietary supplementation. In addition to the natural form of coenzyme Q₁₀, acetylated and succinylated forms were also administered. Coenzyme Q₁₀ was taken up into the blood, but uptake was significantly greater in rats given the succinylated (~40%), and particularly, the acetylated forms (~70%). All three forms increased significantly the total coenzyme Q concentration in both the liver (~100%) and spleen (~130%). Coenzyme Q₁₀ and its esterified forms were not taken up into kidney, heart, muscle or brain. Intraportal and intraperitoneal administration of succinylated coenzyme Q₁₀ gave results similar to those obtained in the dietary experiments. Uptake of the dietary coenzyme Q₁₀ into the liver and spleen did not down-regulate the endogenous synthesis, i.e., the amounts of isolated coenzyme Q₉ did not change in these tissues. Thus, esterification of coenzyme Q increases the uptake of dietary lipid into the blood; however, the derivatization does not contribute to the elevation of coenzyme Q levels in various organs.

KEY WORDS: • coenzyme Q • rats • blood lipids • aging

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