QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chao, W.-H. Articles by Perkins, J. B. Search for Related Content PubMed PubMed Citation Articles by Chao, W.-H. Articles by Perkins, J. B.

---

Research Communication

Oxidative Stress in Humans during Work at Moderate Altitude^{1 ,2}

Wei-Hsun Chao, Eldon W. Askew³, Donald E. Roberts^*, Steven M. Wood and James B. Perkins^**

Division of Foods and Nutrition, University of Utah, Salt Lake City, UT 84112; ^* Department of Human Performance, Naval Health Research Center, San Diego, CA 92152; Medical Nutrition, Ross Products Division, Abbott Laboratories, Columbus, OH 43219; and ^** DataChem Laboratories, Incorporated, Salt Lake City, UT 84123

³To whom correspondence should be addressed.

Increased oxidative stress has been associated with work at high altitude; however, it is not known whether oxidative stress is a significant problem at moderate altitudes. The oxidative stress indicators, breath pentane (BP), 8-hydroxydeoxyguanosine (8-OHdG), oxygen radical absorption capacity (ORAC), 4-hydroxynonenal (4-HNE), malondialdehyde (MDA), and lipid peroxides (LPO) were measured in breath, blood and urine samples of U.S. Marines engaged in moderate altitude (~3000 m) cold weather field training. The test subjects were divided into a placebo and four antioxidant supplement groups (n = 15/group) and received the following supplements for 28 d: 1) vitamin E, 440 -tocopherol equivalents (-TE); 2) vitamin A, 2000 retinol equivalents (RE) of ß-carotene; 3) vitamin C, 500 mg ascorbic acid; 4) a mixture of 440 -TE, 2000 RE of ß-carotene, 500 mg ascorbic acid, 100 µg selenium and 30 mg zinc daily. Strenuous work (~23 MJ/d) in cold weather at moderate altitude was accompanied by increases in several indicators of oxidative stress that were not effectively controlled by conventional antioxidant supplements. The group receiving the antioxidant mixture exhibited lower BP (P < 0.05) compared with those receiving single antioxidant supplements; however, not all markers of oxidative stress responded like BP. Because these markers did not respond in the same manner, it is important to include markers from more than one source to assess the effect of supplemental dietary antioxidants.

KEY WORDS: • oxidative stress • indicators of oxidative stress • antioxidants • breath pentane • exercise • altitude • cold • military rations • humans

This article has been cited by other articles:

				J. K. Baillie, M. G. D. Bates, A. A. R. Thompson, W. S. Waring, R. W. Partridge, M. F. Schnopp, A. Simpson, F. Gulliver-Sloan, S. R. J. Maxwell, and D. J. Webb Endogenous Urate Production Augments Plasma Antioxidant Capacity in Healthy Lowland Subjects Exposed to High Altitude Chest, May 1, 2007; 131(5): 1473 - 1478. [Abstract] [Full Text] [PDF]

				C. L. McGowan, A. S. Levy, P. J. Millar, J. C. Guzman, C. A. Morillo, N. McCartney, and M. J. MacDonald Acute vascular responses to isometric handgrip exercise and effects of training in persons medicated for hypertension Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1797 - H1802. [Abstract] [Full Text] [PDF]

				R. L. Prior Plasma Antioxidant Measurements J. Nutr., November 1, 2004; 134(11): 3184S - 3185S. [Full Text] [PDF]

				J. L. Nelson, P. S. Bernstein, M. C. Schmidt, M. S. Von Tress, and E. W. Askew Dietary Modification and Moderate Antioxidant Supplementation Differentially Affect Serum Carotenoids, Antioxidant Levels and Markers of Oxidative Stress in Older Humans J. Nutr., October 1, 2003; 133(10): 3117 - 3123. [Abstract] [Full Text] [PDF]

				W. H. Ling, L. L. Wang, and J. Ma Supplementation of the Black Rice Outer Layer Fraction to Rabbits Decreases Atherosclerotic Plaque Formation and Increases Antioxidant Status J. Nutr., January 1, 2002; 132(1): 20 - 26. [Abstract] [Full Text] [PDF]

				P. MOLLER, S. LOFT, C. LUNDBY, and N. V. OLSEN Acute hypoxia and hypoxic exercise induce DNA strand breaks and oxidative DNA damage in humans FASEB J, May 1, 2001; 15(7): 1181 - 1186. [Abstract] [Full Text] [PDF]

				D. L. McKay, G. Perrone, H. Rasmussen, G. Dallal, W. Hartman, G. Cao, R. L. Prior, R. Roubenoff, and J. B. Blumberg The Effects of a Multivitamin/Mineral Supplement on Micronutrient Status, Antioxidant Capacity and Cytokine Production in Healthy Older Adults Consuming a Fortified Diet J. Am. Coll. Nutr., October 1, 2000; 19(5): 613 - 621. [Abstract] [Full Text] [PDF]

				G. Cao and R. L. Prior Postprandial increases in serum antioxidant capacity in older women J Appl Physiol, September 1, 2000; 89(3): 877 - 883. [Abstract] [Full Text] [PDF]