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Manuscript received 14 May 1998. Initial reviews completed 11 June 1998. Revision accepted 1 October 1998.
,, and
Center for Human Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile; * Chilean Commission for Nuclear Energy, Santiago, Chile; Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile; and ** Program of Morphology, Faculty of Medicine, University of Chile, Santiago, Chile
This study was conducted to evaluate the effects of single and combined deficiencies of Se, Zn and I on thyroid function in rats. Rats were fed amino acid-based diets for 6 wk starting from weaning. The diets contained either low or adequate amounts of these minerals. In addition to the control and control pair-fed groups, seven experimental groups were formed: Se deficient (Se
); I deficient (I); Zn deficient (Zn); Se and I deficient (SeI); Zn and I deficient (ZnI); Se and Zn deficient (SeZn); and Se, I and Zn deficient (SeIZn). Serum triiodothyronine (T3) was significantly lower than in controls in Zn, SeZn and SeI groups. Serum total thyroxine (T4) and free T4 were significantly lower and thyroid-stimulating hormone (TSH) greater in all iodine-deficient groups, regardless of Se or Zn status. Thyroid glutathione peroxidase activity was significantly reduced in Se and SeZn groups. Nevertheless, in the groups with a concurrent I deficiency, the activity of this enzyme was significantly greater than in controls. Severe alterations of the follicle cellular architecture, including signs compatible with apoptosis, were observed in the Zn and SeZn groups. These alterations appeared to be less severe when iodine deficiency was simultaneously present. Single and multiple deficiencies of Se, Zn and I have distinct effects on thyroid metabolism and structure.
The Journal of Nutrition Vol. 129 No. 1 January 1999,
pp. 174-180
Copyright ©1999 by the American Society for Nutritional Sciences
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