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Taste Sensitivity Is Altered in Patients with Chronic Renal Failure Receiving Continuous Ambulatory Peritoneal Dialysis

Manuscript received 23 December 1997. Initial reviews completed 20 March 1998. Revision accepted 8 October 1998.

Robyn A. Middleton and Margaret A. Allman-Farinelli

Human Nutrition Unit GO8, University of Sydney, New South Wales 2006, Australia

Decreased taste sensitivity may be one of the many factors influencing the poor nutritional status of many patients with chronic renal failure. Several studies examining taste in chronic uremic and hemodialysis (HD) patients indicate decreased sensitivity; continuous ambulatory peritoneal dialysis (CAPD) patients, however, warrant investigation. The aim of this study was to determine if the taste detection threshold for each of the four tastes (sweet, salty, sour and bitter) differs between CAPD patients and age and sex matched controls with normal renal function. The thresholds were determined using Cornsweet's staircase technique for increasing and decreasing stimulus concentration, in which the subject's response determines the next concentration to be tested. A forced-choice design using three samples was used to help minimize bias. The taste detection threshold for the CAPD patients was significantly higher than that of the controls for sodium chloride (salty)(P = 0.001) and quinine (bitter) (P = 0.01). This information may be useful when designing dietary supplements and devising meal plans to help patients consume nutritionally adequate diets.

Key words: continuous ambulatory peritoneal dialysis, hemodialysis, detection threshold, recognition threshold, taste sensitivity, humans.

The Journal of Nutrition Vol. 129 No. 1 January 1999, pp. 122-125
Copyright ©1999 by the American Society for Nutritional Sciences




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A. Y.-M. WANG, M. M.-M. SEA, R. IP, M.-C. LAW, K.-M. CHOW, S.-F. LUI, P. K.-T. LI, and J. WOO
Independent Effects of Residual Renal Function and Dialysis Adequacy on Actual Dietary Protein, Calorie, and Other Nutrient Intake in Patients on Continuous Ambulatory Peritoneal Dialysis
J. Am. Soc. Nephrol., November 1, 2001; 12(11): 2450 - 2457.
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