Journal of Nutrition LabDiet, Your World of Nutritional Answers

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Buemann, B.
Right arrow Articles by Astrup, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Buemann, B.
Right arrow Articles by Astrup, A.

D-Tagatose, a Stereoisomer of D-Fructose, Increases Hydrogen Production in Humans without Affecting 24-Hour Energy Expenditure or Respiratory Exchange Ratio

Manuscript received 22 January 1998. Initial reviews completed 6 March 1998. Revision accepted 21 May 1998.

Benjamin Buemann, Søren Toubro, and Arne Astrup

Research Department of Human Nutrition & Center of Food Research, The Royal Veterinary and Agricultural University, DK 1958 Frederiksberg, Denmark

In growth studies on rats, the ketohexose D-tagatose has been shown to contribute no net metabolizable energy, and a pronounced thermic effect of the sugar has been suggested to account for the absence of energy. In a double-blind and balanced cross-over design, we measured 24-h energy expenditure in eight normal weight humans in a respiration chamber during the consumption of 30 g D-tagatose or 30 g sucrose/d. Metabolic measurements were performed before and after a 2-wk adaptation period with a 30-g daily intake of the test sugar. Total 24-h energy expenditure and hour-by-hour profile were unaffected by the test sugar. The nonprotein respiratory exchange ratio (RERnp) was similar during consumption of D-tagatose and sucrose. However, the effect on RERnp due to CO2 produced by fermentation of D-tagatose could not be quantified in this study. A significant increase in 24-h H2 production (35%) during D-tagatose administration suggests a substantial malabsorption of the sugar. We found no effects of the 2-wk adaptation period on the measured gas exchange variables. Significantly lower fasting plasma insulin and triglyceride concentrations were observed during D-tagatose administration compared with the sucrose period. No effects of D-tagatose on body weight and composition were seen, but the perception of fullness 2.5 h after the sugar load was greater with D-tagatose. In conclusion, this study does not suggest a pronounced thermic effect of D-tagatose, and other mechanisms seem to be required to explain its lack of net energy.

Key words: D-tagatose, energy expenditure, fermentation, humans, hydrogen.

The Journal of Nutrition Vol. 128 No. 9 September 1998, pp. 1481-1486
Copyright ©1998 by the American Society for Nutritional Sciences




This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
L. Normen, H. N Larke, B. B. Jensen, A. M. Langkilde, and H. Andersson
Small-bowel absorption of D-tagatose and related effects on carbohydrate digestibility: an ileostomy study
Am. J. Clinical Nutrition, January 1, 2001; 73(1): 105 - 110.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
H. N. Lærke and B. B. Jensen
D-Tagatose Has Low Small Intestinal Digestibility but High Large Intestinal Fermentability in Pigs
J. Nutr., May 1, 1999; 129(5): 1002 - 1009.
[Abstract] [Full Text]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Copyright © 1998 by American Society for Nutrition