![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Manuscript received 2 February 1998. Initial reviews completed 30 March 1998. Revision accepted 26 May 1998.
Department of Food Engineering and Biotechnology, Technion
Israel Institute of Technology, Haifa, Israel
Fructose intake has increased steadily during the past two decades. Fructose, like other reducing sugars, can react with proteins through the Maillard reaction (glycation), which may account for several complications of diabetes mellitus and accelerating aging. In this study, we evaluated the effect of fructose intake on some age-related variables. Rats were fed for 1 y a commercial nonpurified diet, and had free access to water or 250 g/L solutions of fructose, glucose or sucrose. Early glycation products were evaluated by blood glycated hemoglobin and fructosamine concentrations. Lipid peroxidation was estimated by urine thiobarbituric reactive substances. Skin collagen crosslinking was evaluated by solubilization in natural salt or diluted acetic acid solutions, and by the ratio between 
- and 
-collagen chains. Advanced glycation end products were evaluated by collagen-linked fluorescence in bones. The ratio between type-III and type-I collagens served as an aging variable and was measured in denatured skin collagen. The tested sugars had no effect on plasma glucose concentrations. Blood fructose, cholesterol, fructosamine and glycated hemoglobin levels, and urine lipid peroxidation products were significantly higher in fructose-fed rats compared with the other sugar-fed and control rats. Acid-soluble collagen and the type-III to type-I ratio were significantly lower, whereas insoluble collagen, the to ratio and collagen-bound fluorescence at 335/385 nm (excitation/emission) were significantly higher in fructose-fed rats than in the other groups. The data suggest that long-term fructose consumption induces adverse effects on aging; further studies are required to clarify the precise role of fructose in the aging process.
The Journal of Nutrition Vol. 128 No. 9 September 1998,
pp. 1442-1449
Copyright ©1998 by the American Society for Nutritional Sciences
This article has been cited by other articles:
|
|
 |
|
  P. J Havel, S. S Elliott, J. S Stern, N. L Keim, and K. Teff Reply to TJ Vasankari Am. J. Clinical Nutrition, October 1, 2003; 78(4): 805 - 806. [Full Text] [PDF]
|
|
|
|
 |
|
 J. Busserolles, E. Gueux, E. Rock, A. Mazur, and Y. Rayssiguier Substituting Honey for Refined Carbohydrates Protects Rats from Hypertriglyceridemic and Prooxidative Effects of Fructose J. Nutr., November 1, 2002; 132(11): 3379 - 3382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. SELL, N. R. KLEINMAN, and V. M. MONNIER Longitudinal determination of skin collagen glycation and glycoxidation rates predicts early death in C57BL/6NNIA mice FASEB J, January 1, 2000; 14(1): 145 - 156. [Abstract] [Full Text]
|
|
