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Increased Serum Cholesterol in Healthy Human Methane Producers Is Confounded by Age

Manuscript received 13 November 1997. Initial reviews completed 28 January 1998. Revision accepted 13 April 1998.

Judlyn Fernandes*, Thomas M. S. Wolever*, dagger , , and A. Venketeshwer Rao*

* Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 3E2 and dagger  Clinical Nutrition and Risk Factor Modification Centre and Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Ontario, Canada M5C 2T2

It has been theorized that colonic production and absorption of short-chain fatty acids (SCFA) is different in methane producers (MP) compared with nonproducers (MNP). Because colonic SCFA may influence systemic lipid metabolism, blood lipids may differ in MP and MNP. To compare serum lipids and SCFA in fasting MP and MNP, we measured breath gases, serum lipids and SCFA in 167 healthy subjects and excluded subjects with abnormal blood lipids. The 66 MP were significantly older than the 63 MNP (49.5 ± 16.0 vs. 39.6 ± 17.0 y, P = 0.0009), and breath methane concentrations were weakly correlated with age in MP (r = 0.268, P = 0.03). Mean serum cholesterol was significantly higher in MP compared with MNP, but the differences were not significant after adjusting for age. No significant differences were observed in serum SCFA between the two groups. This study has shown that breath methane increases with age, which may be due to age-related increases in transit time and carbohydrate malabsorption. These results provide no conclusive link between colonic events and serum lipids in MP because, with age, methane production increased as did serum cholesterol. More research is required before any definite conclusions can be drawn.

Key words: humans, methane, cholesterol, short-chain fatty acids, colonic fermentation.

The Journal of Nutrition Vol. 128 No. 8 August 1998, pp. 1349-1354
Copyright ©1998 by the American Society for Nutritional Sciences




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