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Dorsomedial Hypothalamic Lesions Alter Intake of an Imbalanced Amino Acid Diet in Rats

Manuscript received 14 April 1997. Initial reviews completed 20 June 1997. Revision accepted 17 March 1998.

Larry L. Bellinger, James F. Evans, and Dorothy W. Gietzen*

Department of Biomedical Sciences, The Texas A & M University System, Baylor College of Dentistry, Dallas, TX 75246 and * Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, and Food Intake Laboratory, University of California, Davis, CA, 95616

Within 3 h of ingesting an imbalanced amino acid diet (IAAD), rats show attenuated intake. The associated conditioned taste aversion can be ameliorated by giving the serotonin3 receptor blocker, tropisetron (TROP). A recent c-fos study indicated that the dorsomedial hypothalamic nucleus (DMN) may be activated 2-3 h after ingestion of IAAD. In Experiment 1, DMN-lesioned rats (DMNL) or sham-operated (SHAM) rats were injected with saline (SAL) or TROP just before introduction of IAAD. By 3 h, SAL-DMNL rats consumed more (P < 0.01) of the IAAD than did the SAL-SHAM rats. Thereafter, over the next 21 h, the intake of the SAL-DMNL group returned to control levels. TROP treatment enhanced the intake of the treated groups; the TROP and the lesion effect were additive (P < 0.01). By d 4 of receiving the IAAD, the DMNL groups were eating less than SHAM rats (P < 0.05). The data suggest that the DMN may be involved in the early detection of the amino acid deficiency induced by IAAD, is not involved in the TROP effect and is necessary for proper long-term adaptation to an IAAD.

Key words: body weight, serotonin3 receptors, feeding, rats, essential amino acid deficiency.

The Journal of Nutrition Vol. 128 No. 7 July 1998, pp. 1213-1217
Copyright ©1998 by the American Society for Nutritional Sciences




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Copyright © 1998 by American Society for Nutrition