![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Manuscript received 8 September 1997. Initial reviews completed 13 October 1997. Revision accepted 27 March 1998.
Department of Foods & Nutrition and * Department of Animal Sciences, Purdue University, West Lafayette, IN 47907
Psyllium, a source of dietary fiber rich in soluble components results in lower serum cholesterol concentration in several species. Suggested mechanisms for the hypocholesterolemic effect include a greater excretion of fecal bile acids and total steroids, and up-regulation of bile acid biosynthesis. The activity of cholesterol 7
-hydroxylase (7OHase), the rate limiting enzyme in bile acid biosynthesis, is higher in rats fed 5% psyllium. Whether this higher activity corresponds to an increase in mRNA levels has not been determined. Four groups of 10 rats were fed a semipurified diet containing 5% cellulose (CEL; control), 5% cellulose plus 1% cholic acid (CCA), 5% cellulose plus 2% cholestyramine (CHY) or 5% psyllium hydrocolloid (PSY) for 3 wk. Liver cholesterol concentration, fecal bile acid and total steroid excretion, 7OHase activity and 7OHase mRNA levels were measured. Liver cholesterol content in rats fed CCA was significantly higher than in all other groups. Rats fed CHY and PSY had significantly lower liver cholesterol content than those fed CEL. Total fecal steroid and bile acid excretions were significantly greater in rats fed CCA, CHY and PSY than in those fed CEL. Activities and mRNA levels of 7OHase in rats fed CHY and PSY were significantly higher than in rats fed CEL or CCA. These data indicate that feeding psyllium to rats increases fecal bile acid and total steroid excretion as well as 7OHase activity and 7OHase mRNA levels.
The Journal of Nutrition Vol. 128 No. 7 July 1998,
pp. 1199-1203
Copyright ©1998 by the American Society for Nutritional Sciences
This article has been cited by other articles:
|
|
 |
|
  M. Fukushima, T. Ohashi, Y. Fujiwara, K. Sonoyama, and M. Nakano Cholesterol-Lowering Effects of Maitake (Grifola frondosa) Fiber, Shiitake (Lentinus edodes) Fiber, and Enokitake (Flammulina velutipes) Fiber in Rats Experimental Biology and Medicine, September 1, 2001; 226(8): 758 - 765. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Buhman, E. J. Furumoto, S. S. Donkin, and J. A. Story Dietary Psyllium Increases Expression of Ileal Apical Sodium-Dependent Bile Acid Transporter mRNA Coordinately with Dose-Responsive Changes in Bile Acid Metabolism in Rats ,2 J. Nutr., September 1, 2000; 130(9): 2137 - 2142. [Abstract] [Full Text]
|
|
|
|
|
|
M. Fukushima, M. Nakano, Y. Morii, T. Ohashi, Y. Fujiwara, and K. Sonoyama Hepatic LDL Receptor mRNA in Rats Is Increased by Dietary Mushroom (Agaricus bisporus) Fiber and Sugar Beet Fiber J. Nutr., September 1, 2000; 130(9): 2151 - 2156. [Abstract] [Full Text]
|
|
|
|
|
|
E. A. Trautwein, A. Kunath-Rau, and H. F. Erbersdobler Increased Fecal Bile Acid Excretion and Changes in the Circulating Bile Acid Pool Are Involved in the Hypocholesterolemic and Gallstone-Preventive Actions of Psyllium in Hamsters J. Nutr., April 1, 1999; 129(4): 896 - 902. [Abstract] [Full Text]
|
|
